Version 5.4
| Homo sapiens Gene: CLCA2 | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-100078.6 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | CLCA2 | ||||||||||||||||||
| Gene Name | chloride channel accessory 2 | ||||||||||||||||||
| Synonyms | CACC; CaCC-3; CACC3; CLCRG2 | ||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Gene | ENSG00000137975 | ||||||||||||||||||
| Encoded Proteins |
chloride channel accessory 2
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| Summary |
The protein encoded by this gene belongs to the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same site on chromosome 1p31-p22 and share high degrees of homology in size, sequence and predicted structure, but differ significantly in their tissue distributions. Since this protein is expressed predominantly in trachea and lung, it is suggested to play a role in the complex pathogenesis of cystic fibrosis. It may also serve as adhesion molecule for lung metastatic cancer cells, mediating vascular arrest and colonization, and furthermore, it has been implicated to act as a tumor suppressor gene for breast cancer. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 1:86424086-86456558 | ||||||||||||||||||
| Strand | Forward strand | ||||||||||||||||||
| Band | p22.3 | ||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
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Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||
| NETPATH |
Alpha6Beta4Integrin pathway
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| REACTOME |
Stimuli-sensing channels pathway
Transmembrane transport of small molecules pathway
Orphan transporters pathway
Ion channel transport pathway
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| KEGG |
Olfactory transduction pathway
Pancreatic secretion pathway
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| INOH | |||||||||||||||||||
| PID NCI |
p73 transcription factor network
Validated transcriptional targets of TAp63 isoforms
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| Cross-References | |||||||||||||||||||
| SwissProt | Q9UQC9 | ||||||||||||||||||
| TrEMBL | |||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | 9635 | ||||||||||||||||||
| UniGene | Hs.241551 Hs.598474 | ||||||||||||||||||
| RefSeq | NM_006536 | ||||||||||||||||||
| HUGO | HGNC:2016 | ||||||||||||||||||
| OMIM | 604003 | ||||||||||||||||||
| CCDS | CCDS708 | ||||||||||||||||||
| HPRD | 04923 | ||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | AB026833 AF043977 AF127980 AK290348 BC041096 CH471097 | ||||||||||||||||||
| GenPept | AAD40367 AAD48397 AAH41096 BAA77810 BAF83037 EAW73187 | ||||||||||||||||||
| RNA Seq Atlas | 9635 | ||||||||||||||||||