InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: HS2ST1

Summary

InnateDB Gene

IDBG-100108.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HS2ST1

Gene Name

heparan sulfate 2-O-sulfotransferase 1

Synonyms

dJ604K5.2

Species

Homo sapiens

Ensembl Gene

ENSG00000153936

Encoded Proteins

IDBP-100110

heparan sulfate 2-O-sulfotransferase 1

IDBP-100112

heparan sulfate 2-O-sulfotransferase 1

IDBP-722227

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 26150541

[Mus musculus] Inactivation of Hs2st1 in neutrophils substantially reduces their bactericidal activity, and Hs2st1-deficient mice are more susceptible to systemic infection with the pathogenic bacterium group B Streptococcus.

Entrez Gene

Summary

Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities. This gene encodes a member of the heparan sulfate biosynthetic enzyme family that transfers sulfate to the 2 position of the iduronic acid residue of heparan sulfate. The disruption of this gene resulted in no kidney formation in knockout embryonic mice, indicating that the absence of this enzyme may interfere with the signaling required for kidney formation. Two alternatively spliced transcript variants that encode different proteins have been found for this gene. [provided by RefSeq, Aug 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:86914648-87109998

Strand

Forward strand

Band

p22.3

Transcripts

ENST00000370551	ENSP00000359582
ENST00000370550	ENSP00000359581
ENST00000591456	ENSP00000467253

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001733	galactosylceramide sulfotransferase activity
GO:0008146	sulfotransferase activity

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006024	glycosaminoglycan biosynthetic process
GO:0008152	metabolic process
GO:0009058	biosynthetic process
GO:0030203	glycosaminoglycan metabolic process
GO:0044281	small molecule metabolic process