InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PRMT6

Summary

InnateDB Gene

IDBG-100613.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PRMT6

Gene Name

protein arginine methyltransferase 6

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000198890

Encoded Proteins

IDBP-100615

protein arginine methyltransferase 6

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene belongs to the arginine N-methyltransferase family, which catalyze the sequential transfer of methyl group from S-adenosyl-L-methionine to the side chain nitrogens of arginine residues within proteins, to form methylated arginine derivatives and S-adenosyl-L-homocysteine. This protein can catalyze both, the formation of omega-N monomethylarginine and asymmetrical dimethylarginine, with a strong preference for the latter. It specifically mediates the asymmetric dimethylation of Arg2 of histone H3, and the methylated form represents a specific tag for epigenetic transcriptional repression. This protein also forms a complex with, and methylates DNA polymerase beta, resulting in stimulation of polymerase activity by enhancing DNA binding and processivity. [provided by RefSeq, Sep 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:107056679-107059294

Strand

Forward strand

Band

p13.3

Transcripts

ENST00000370078

ENSP00000359095

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 172 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	172 [view]
Protein-Protein	172 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008168	methyltransferase activity
GO:0008276	protein methyltransferase activity
GO:0016740	transferase activity
GO:0035241	protein-arginine omega-N monomethyltransferase activity
GO:0035242	protein-arginine omega-N asymmetric methyltransferase activity
GO:0042054	histone methyltransferase activity
GO:0042393	histone binding
GO:0044020	histone methyltransferase activity (H4-R3 specific)
GO:0070611	histone methyltransferase activity (H3-R2 specific)
GO:0070612	histone methyltransferase activity (H2A-R3 specific)

Biological Process

GO:0006284	base-excision repair
GO:0006351	transcription, DNA-templated
GO:0006479	protein methylation
GO:0008152	metabolic process
GO:0016032	viral process
GO:0016571	histone methylation
GO:0019919	peptidyl-arginine methylation, to asymmetrical-dimethyl arginine
GO:0034970	histone H3-R2 methylation
GO:0043985	histone H4-R3 methylation
GO:0045892	negative regulation of transcription, DNA-templated

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000049300

View Gene Order

ENSBTAG00000039951

Not yet available

Pathways

NETPATH

REACTOME

REACT_172623

Chromatin organization pathway

REACT_228108

RMTs methylate histone arginines pathway

REACT_172633

Chromatin modifying enzymes pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

Q96LA8

TrEMBL

UniProt Splice Variant

Entrez Gene

55170

UniGene

Hs.26006 Hs.644402

RefSeq

NM_018137

HUGO

HGNC:18241

OMIM

608274

CCDS

CCDS41360

HPRD

IMGT

EMBL

AK001421 AK295541 AL355539 AY043278 BC002729 BC063446 BC073866 BX475300 CH471156

GenPept

AAH02729 AAH63446 AAH73866 AAK85733 BAA91681 BAG58450 CAI19090 EAW51248

RNA Seq Atlas

55170