Version 5.4
Homo sapiens Gene: AMPD2
Summary
InnateDB Gene IDBG-100855.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AMPD2
Gene Name adenosine monophosphate deaminase 2
Synonyms PCH9; SPG63
Species Homo sapiens
Ensembl Gene ENSG00000116337
Encoded Proteins
IDBP-100857
adenosine monophosphate deaminase 2
IDBP-100861
adenosine monophosphate deaminase 2
IDBP-100863
adenosine monophosphate deaminase 2
IDBP-100865
adenosine monophosphate deaminase 2
IDBP-243113
adenosine monophosphate deaminase 2
IDBP-583836
adenosine monophosphate deaminase 2
IDBP-583165
adenosine monophosphate deaminase 2
IDBP-599107
adenosine monophosphate deaminase 2
IDBP-602118
adenosine monophosphate deaminase 2
IDBP-585176
adenosine monophosphate deaminase 2
IDBP-589238
adenosine monophosphate deaminase 2
IDBP-596724
adenosine monophosphate deaminase 2
IDBP-593549
adenosine monophosphate deaminase 2
IDBP-597372
adenosine monophosphate deaminase 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is important in purine metabolism by converting AMP to IMP. The encoded protein, which acts as a homotetramer, is one of three AMP deaminases found in mammals. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:109616104-109632051
Strand Forward strand
Band p13.3
Transcripts
ENST00000342115 ENSP00000345498
ENST00000256578 ENSP00000256578
ENST00000358729 ENSP00000351573
ENST00000369840 ENSP00000358855
ENST00000393688 ENSP00000377292
ENST00000474459 ENSP00000432344
ENST00000469039 ENSP00000436303
ENST00000486282
ENST00000459643
ENST00000467071
ENST00000479919
ENST00000476688 ENSP00000437025
ENST00000531734 ENSP00000433739
ENST00000526301
ENST00000528667 ENSP00000436541
ENST00000531203 ENSP00000431975
ENST00000528270 ENSP00000434891
ENST00000527846 ENSP00000431904
ENST00000528454 ENSP00000437164
ENST00000534144
ENST00000525415
ENST00000524975
ENST00000529299
ENST00000532851
ENST00000533132
ENST00000528958
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003876 AMP deaminase activity
GO:0019239 deaminase activity
GO:0046872 metal ion binding
Biological Process
GO:0006144 purine nucleobase metabolic process
GO:0006188 IMP biosynthetic process
GO:0009117 nucleotide metabolic process
GO:0032264 IMP salvage
GO:0043101 purine-containing compound salvage
GO:0044281 small molecule metabolic process
GO:0052652 cyclic purine nucleotide metabolic process
GO:0055086 nucleobase-containing small molecule metabolic process
GO:0097009 energy homeostasis
Cellular Component
GO:0005575 cellular_component
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000027889
View Gene Order
ENSBTAG00000013018
Not yet available
Pathways
NETPATH
REACTOME
REACT_1923
Purine salvage pathway
REACT_1698
Metabolism of nucleotides pathway
REACT_522
Purine metabolism pathway
REACT_111217
Metabolism pathway
KEGG
hsa00230
Purine metabolism pathway
INOH
INOH website
Purine nucleotides nucleosides metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.82927
RefSeq NM_001257360 NM_001257361 NM_004037 NM_139156 NM_203404 XM_005270752 XM_006710576
HUGO
OMIM
CCDS CCDS30796 CCDS58016 CCDS804 CCDS805
HPRD 11808
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca