Version 5.4
Homo sapiens Gene: GSTM1
Summary
InnateDB Gene IDBG-100889.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GSTM1
Gene Name glutathione S-transferase mu 1
Synonyms GST1; GSTM1-1; GSTM1a-1a; GSTM1b-1b; GTH4; GTM1; H-B; MU; MU-1
Species Homo sapiens
Ensembl Gene ENSG00000134184
Encoded Proteins
IDBP-100891
glutathione S-transferase mu 1
IDBP-100893
glutathione S-transferase mu 1
IDBP-100895
glutathione S-transferase mu 1
IDBP-100897
glutathione S-transferase mu 1
IDBP-721792
IDBP-722415
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Null mutations of this class mu gene have been linked with an increase in a number of cancers, likely due to an increased susceptibility to environmental toxins and carcinogens. Multiple protein isoforms are encoded by transcript variants of this gene. [provided by RefSeq, Jul 2008]
Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual\'s susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Null mutations of this class mu gene have been linked with an increase in a number of cancers, likely due to an increased susceptibility to environmental toxins and carcinogens. Multiple protein isoforms are encoded by transcript variants of this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:109687814-109709039
Strand Forward strand
Band p13.3
Transcripts
ENST00000309851 ENSP00000311469
ENST00000349334 ENSP00000234981
ENST00000369823 ENSP00000358838
ENST00000369819 ENSP00000358834
ENST00000490021
ENST00000483399 ENSP00000455929
ENST00000476065 ENSP00000456315
ENST00000490171
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004364 glutathione transferase activity
GO:0005515 protein binding
GO:0019899 enzyme binding
GO:0042803 protein homodimerization activity
GO:0043295 glutathione binding
Biological Process
GO:0006749 glutathione metabolic process
GO:0006805 xenobiotic metabolic process
GO:0008152 metabolic process
GO:0018916 nitrobenzene metabolic process
GO:0042178 xenobiotic catabolic process
GO:0044281 small molecule metabolic process
GO:0045087 innate immune response
GO:0070458 cellular detoxification of nitrogen compound
GO:1901687 glutathione derivative biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_6926
Glutathione conjugation pathway
REACT_6959
Phase II conjugation pathway
REACT_111217
Metabolism pathway
REACT_13433
Biological oxidations pathway
KEGG
hsa00480
Glutathione metabolism pathway
hsa00980
Metabolism of xenobiotics by cytochrome P450 pathway
hsa00982
Drug metabolism pathway
INOH
PID NCI
cmyb_pathway
C-MYB transcription factor network
Cross-References
SwissProt
TrEMBL B9ZVX7
UniProt Splice Variant
Entrez Gene 2944
UniGene Hs.301961 Hs.595978
RefSeq NM_000561 NM_146421 XM_005270782 XM_005270783
HUGO HGNC:4632
OMIM 138350
CCDS CCDS809 CCDS810
HPRD 00707
IMGT
EMBL AC000031 AC000032
GenPept
RNA Seq Atlas 2944

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca