InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ATP5F1

Summary

InnateDB Gene

IDBG-101064.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ATP5F1

Gene Name

ATP synthase, H+ transporting, mitochondrial Fo complex, subunit B1

Synonyms

PIG47

Species

Homo sapiens

Ensembl Gene

ENSG00000116459

Encoded Proteins

IDBP-101066

ATP synthase, H+ transporting, mitochondrial Fo complex, subunit B1

IDBP-484456

ATP synthase, H+ transporting, mitochondrial Fo complex, subunit B1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene encodes the b subunit of the proton channel. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:111448864-111462773

Strand

Forward strand

Band

p13.2

Transcripts

ENST00000369722	ENSP00000358737
ENST00000369721
ENST00000493119
ENST00000483994	ENSP00000420366
ENST00000468818
ENST00000464154

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.

Experimentally validated
Total	22 [view]
Protein-Protein	21 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0015078	hydrogen ion transmembrane transporter activity
GO:0016887	ATPase activity
GO:0022857	transmembrane transporter activity
GO:0046933	proton-transporting ATP synthase activity, rotational mechanism

Biological Process

GO:0006200	ATP catabolic process
GO:0015986	ATP synthesis coupled proton transport
GO:0021762	substantia nigra development
GO:0022904	respiratory electron transport chain
GO:0042776	mitochondrial ATP synthesis coupled proton transport
GO:0044237	cellular metabolic process
GO:0044281	small molecule metabolic process

Cellular Component

GO:0000276	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
GO:0005634	nucleus
GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005753	mitochondrial proton-transporting ATP synthase complex
GO:0005759	mitochondrial matrix
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000000563

View Gene Order

ENSBTAG00000006441

Not yet available

Pathways

NETPATH

REACTOME

REACT_6759

Formation of ATP by chemiosmotic coupling pathway

REACT_6305

Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. pathway

REACT_111083

The citric acid (TCA) cycle and respiratory electron transport pathway

REACT_111217

Metabolism pathway

KEGG

hsa05010

Alzheimer's disease pathway

hsa00190

Oxidative phosphorylation pathway

hsa05012

Parkinson's disease pathway

hsa05016

Huntington's disease pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.514870 Hs.572510 Hs.646470 Hs.664187 Hs.736082

RefSeq

NM_001688 XM_005270929

HUGO

OMIM

CCDS

CCDS836

HPRD

04467

IMGT

EMBL

GenPept

RNA Seq Atlas