Homo sapiens Gene: ATP5F1

Summary
InnateDB Gene IDBG-101064.5
Last Modified 2012-02-14   [Report errors or provide feedback]
Gene Symbol ATP5F1
Gene Name ATP synthase, H+ transporting, mitochondrial Fo complex, subunit B1
Synonyms PIG47
Species Homo sapiens
Ensembl Gene ENSG00000116459
Encoded Proteins
IDBP-101066 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit B1
IDBP-484456 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit B1
Entrez Gene
Summary This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene encodes the b subunit of the proton channel. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1: 111991486-112005395
Strand Forward strand
Band p13.2
Transcripts
ENST00000369722  ENSP00000358737
ENST00000369721 
ENST00000493119 
ENST00000483994  ENSP00000420366
ENST00000468818 
ENST00000464154 
Interactions
Number of Interactions   This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
Experimentally validated
Total 25 [view]
Protein‑Protein  25
[view]
Protein‑DNA 0
Protein‑RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
 
Gene Ontology
Accession GO Term
Molecular Function
GO:0005515 protein binding
GO:0015078 hydrogen ion transmembrane transporter activity
GO:0016887 ATPase activity
GO:0022857 transmembrane transporter activity
GO:0046933 hydrogen ion transporting ATP synthase activity, rotational mechanism
Biological Process
GO:0006200 ATP catabolic process
GO:0015986 ATP synthesis coupled proton transport
GO:0022904 respiratory electron transport chain
GO:0042776 mitochondrial ATP synthesis coupled proton transport
GO:0044281 small molecule metabolic process
Cellular Component
GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005753 mitochondrial proton-transporting ATP synthase complex
GO:0005759 mitochondrial matrix
Orthologs
Species
Mus musculus
Bos taurus
Gene ID Gene Order Method Confidence Comments
ENSMUSG00000000563 Ortholuge SSD Ortholog Ortholog supports species divergence
ENSBTAG00000006441 Not yet available Ortholuge SSD Ortholog Ortholog supports species divergence
Pathways
NETPATH
REACTOME
REACT_6759 Formation of ATP by chemiosmotic coupling
KEGG
hsa05010  Alzheimer`s disease
hsa05016  Huntington`s disease
hsa01100  Metabolic pathways
hsa00190  Oxidative phosphorylation
hsa05012  Parkinson`s disease
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt P24539 
TrEMBL Q08ET0 Q5QNZ2
UniProt Splice Variant
Entrez Gene 515 
UniGene Hs.514870 Hs.572510 Hs.646470 Hs.664187 Hs.736082
RefSeq NM_001688 
HUGO 840 
OMIM 603270
CCDS CCDS836 
HPRD 04467
IMGT
EMBL AK313541 AL390195 AY871272 BC005366 BC005960 BC016350 CH471122 X60221
GenPept AAH05366  AAH05960  AAH16350  AAX11428  BAG36318  CAA42782  CAC36042  CAI15628  EAW56495 
ImmGen ATP5F1 (murine) 
RNA Seq Atlas 515