Version 5.4
Homo sapiens Gene: CAPZA1
Summary
InnateDB Gene IDBG-101148.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CAPZA1
Gene Name capping protein (actin filament) muscle Z-line, alpha 1
Synonyms CAPPA1; CAPZ; CAZ1
Species Homo sapiens
Ensembl Gene ENSG00000116489
Encoded Proteins
IDBP-101150
capping protein (actin filament) muscle Z-line, alpha 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary CAPZA1 is a member of the F-actin capping protein alpha subunit family. This gene encodes the alpha subunit of the barbed-end actin binding protein. The protein regulates growth of the actin filament by capping the barbed end of growing actin filaments. [provided by RefSeq, Jul 2008]
CAPZA1 is a member of the F-actin capping protein alpha subunit family. This gene encodes the alpha subunit of the barbed-end actin binding protein. The protein regulates growth of the actin filament by capping the barbed end of growing actin filaments. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:112619173-112671619
Strand Forward strand
Band p13.2
Transcripts
ENST00000263168 ENSP00000263168
ENST00000485542
ENST00000476936
ENST00000498626
ENST00000466066
ENST00000476820
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 60 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 60 [view]
Protein-Protein 56 [view]
Protein-DNA 3 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005515 protein binding
GO:0051015 actin filament binding
Biological Process
GO:0006461 protein complex assembly
GO:0006928 cellular component movement
GO:0007596 blood coagulation
GO:0030036 actin cytoskeleton organization
GO:0045087 innate immune response
GO:0051016 barbed-end actin filament capping
GO:0051693 actin filament capping
Cellular Component
GO:0005576 extracellular region
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005911 cell-cell junction
GO:0008290 F-actin capping protein complex
GO:0015629 actin cytoskeleton
GO:0016020 membrane
GO:0030863 cortical cytoskeleton
GO:0070062 extracellular vesicular exosome
GO:0071203 WASH complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000070372
View Gene Order
ENSBTAG00000014295
Not yet available
Pathways
NETPATH
REACTOME
REACT_25195
Advanced glycosylation endproduct receptor signaling pathway
REACT_24970
Factors involved in megakaryocyte development and platelet production pathway
REACT_6802
Innate Immune System pathway
REACT_6900
Immune System pathway
REACT_604
Hemostasis pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.743370
RefSeq NM_006135
HUGO
OMIM
CCDS CCDS30805
HPRD 03347
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca