Version 5.4
Homo sapiens Gene: VTCN1
Summary
InnateDB Gene IDBG-101440.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol VTCN1
Gene Name V-set domain containing T cell activation inhibitor 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000134258
Encoded Proteins
IDBP-101442
V-set domain containing T cell activation inhibitor 1
IDBP-101444
V-set domain containing T cell activation inhibitor 1
IDBP-101450
V-set domain containing T cell activation inhibitor 1
IDBP-595714
V-set domain containing T cell activation inhibitor 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein belonging to the B7 costimulatory protein family. Proteins in this family are present on the surface of antigen-presenting cells and interact with ligand bound to receptors on the surface of T cells. Studies have shown that high levels of the encoded protein has been correlated with tumor progression. A pseudogene of this gene is located on chromosome 20. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:117143587-117210960
Strand Reverse strand
Band p12
Transcripts
ENST00000369458 ENSP00000358470
ENST00000359008 ENSP00000351899
ENST00000328189 ENSP00000328168
ENST00000463461
ENST00000488493
ENST00000539893 ENSP00000444724
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005515 protein binding
Biological Process
GO:0001562 response to protozoan
GO:0002376 immune system process
GO:0042102 positive regulation of T cell proliferation
GO:0050868 negative regulation of T cell activation
GO:0072602 interleukin-4 secretion
GO:0072643 interferon-gamma secretion
GO:1900042 positive regulation of interleukin-2 secretion
Cellular Component
GO:0009897 external side of plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000051076
View Gene Order
ENSBTAG00000014466
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04514
Cell adhesion molecules (CAMs) pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.546434 Hs.622264
RefSeq NM_001253849 NM_001253850 NM_024626
HUGO
OMIM
CCDS CCDS58019 CCDS58020 CCDS894
HPRD 06429
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca