Version 5.4
Homo sapiens Gene: DUOX1
Summary
InnateDB Gene IDBG-10154.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DUOX1
Gene Name dual oxidase 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000137857
Encoded Proteins
IDBP-10156
dual oxidase 1
IDBP-10162
dual oxidase 1
IDBP-595124
dual oxidase 1
IDBP-595888
dual oxidase 1
IDBP-602437
dual oxidase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 18511861
DUOX1 and DUOX2 localize to the apical plasma membrane of epithelial cells in major airways, salivary glands, and the gastrointestinal tract, and provide extracellular hydrogen peroxide to lactoperoxidase to produce antimicrobial hypothiocyanite ions. Expression of dual oxidases DUOX2 and DUOX1 is regulated by Th1 and Th2 cytokines in human airways.
Entrez Gene
Summary The protein encoded by this gene is a glycoprotein and a member of the NADPH oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter, thyroperoxidase, and a peroxide generating system that includes proteins encoded by this gene and the similar DUOX2 gene. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain. This protein generates hydrogen peroxide and thereby plays a role in the activity of thyroid peroxidase, lactoperoxidase, and in lactoperoxidase-mediated antimicrobial defense at mucosal surfaces. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:45129933-45165576
Strand Forward strand
Band q21.1
Transcripts
ENST00000321429 ENSP00000317997
ENST00000389037 ENSP00000373689
ENST00000558322 ENSP00000454121
ENST00000561220 ENSP00000452623
ENST00000558991
ENST00000561166 ENSP00000454065
ENST00000559219
ENST00000557893
ENST00000558446
ENST00000559716
ENST00000559221
ENST00000558744
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004601 peroxidase activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0016174 NAD(P)H oxidase activity
GO:0016491 oxidoreductase activity
GO:0020037 heme binding
GO:0050661 NADP binding
Biological Process
GO:0006590 thyroid hormone generation
GO:0006979 response to oxidative stress
GO:0019221 cytokine-mediated signaling pathway
GO:0042335 cuticle development
GO:0042446 hormone biosynthetic process
GO:0042554 superoxide anion generation
GO:0042744 hydrogen peroxide catabolic process
GO:0045087 innate immune response (InnateDB)
GO:0050665 hydrogen peroxide biosynthetic process
GO:0051591 response to cAMP
GO:0055114 oxidation-reduction process
GO:0072593 reactive oxygen species metabolic process
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0016324 apical plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000033268
View Gene Order
ENSBTAG00000016246
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.272813
RefSeq NM_017434 NM_175940 XM_005254463
HUGO
OMIM
CCDS CCDS32221
HPRD 08421
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca