InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: FCGR1B

Summary

InnateDB Gene

IDBG-101565.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FCGR1B

Gene Name

Fc fragment of IgG, high affinity Ib, receptor (CD64)

Synonyms

CD64b; IGFRB

Species

Homo sapiens

Ensembl Gene

ENSG00000198019

Encoded Proteins

IDBP-101567

Fc fragment of IgG, high affinity Ib, receptor (CD64)

IDBP-101569

Fc fragment of IgG, high affinity Ib, receptor (CD64)

IDBP-808219

Fc fragment of IgG, high affinity Ib, receptor (CD64)

IDBP-808212

Fc fragment of IgG, high affinity Ib, receptor (CD64)

IDBP-808201

Fc fragment of IgG, high affinity Ib, receptor (CD64)

IDBP-808221

Fc fragment of IgG, high affinity Ib, receptor (CD64)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The gene represents one of three related immunoglobulin gamma Fc receptor genes located on chromosome 1. This family member lacks the transmembrane and coiled-coiled domains found in other family members and is thought to be a pseudogene of Fc-gamma-receptor 1A. [provided by RefSeq, Apr 2009] Three distinct, but closely related classes of receptors that bind the Fc portion of IgG have been identified (Fcgamma RI, II and III). The FcgammaRI family consists of three closely related genes termed A, B, and C. This gene encodes the low affinity FcgammaRIB receptor that may play an important role in humoral immune response. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]
Three distinct, but closely related classes of receptors that bind the Fc portion of IgG have been identified (Fcgamma RI, II and III). The FcgammaRI family consists of three closely related genes termed A, B, and C. This gene encodes the low affinity FcgammaRIB receptor that may play an important role in humoral immune response. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:121087345-121096310

Strand

Forward strand

Band

p11.2

Transcripts

ENST00000369384	ENSP00000358391
ENST00000369383	ENSP00000358390
ENST00000369178	ENSP00000481411
ENST00000466915
ENST00000472543	ENSP00000479641
ENST00000471609
ENST00000616817	ENSP00000478655
ENST00000615565
ENST00000623603	ENSP00000485498

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019763	immunoglobulin receptor activity
GO:0019864	IgG binding

Biological Process

GO:0002474	antigen processing and presentation of peptide antigen via MHC class I
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0006955	immune response
GO:0019221	cytokine-mediated signaling pathway
GO:0038093	Fc receptor signaling pathway
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0060333	interferon-gamma-mediated signaling pathway

Cellular Component

GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0030669	clathrin-coated endocytic vesicle membrane
GO:0031901	early endosome membrane