Version 5.4
Homo sapiens Gene: CBX3
Summary
InnateDB Gene IDBG-10171.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CBX3
Gene Name chromobox homolog 3
Synonyms HECH; HP1-GAMMA; HP1Hs-gamma
Species Homo sapiens
Ensembl Gene ENSG00000122565
Encoded Proteins
IDBP-10173
chromobox homolog 3
IDBP-237616
chromobox homolog 3
IDBP-294711
chromobox homolog 3
IDBP-368975
chromobox homolog 3
IDBP-810726
chromobox homolog 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by this gene binds DNA and is a component of heterochromatin. This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane. This protein binds histone H3 tails methylated at Lys-9 sites. This protein is also recruited to sites of ultraviolet-induced DNA damage and double-strand breaks. Two transcript variants encoding the same protein but differing in the 5' UTR, have been found for this gene.[provided by RefSeq, Mar 2011]
At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by this gene binds DNA and is a component of heterochromatin. This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane. This protein binds histone H3 tails methylated at Lys-9 sites. This protein is also recruited to sites of ultraviolet-induced DNA damage and double-strand breaks. Two transcript variants encoding the same protein but differing in the 5\' UTR, have been found for this gene.[provided by RefSeq, Mar 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:26201162-26213356
Strand Forward strand
Band p15.2
Transcripts
ENST00000337620 ENSP00000336687
ENST00000396386 ENSP00000379670
ENST00000409747 ENSP00000387348
ENST00000456948 ENSP00000408672
ENST00000497498
ENST00000481300
ENST00000462165 ENSP00000473748
ENST00000481057
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 126 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated
Total 126 [view]
Protein-Protein 122 [view]
Protein-DNA 3 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019899 enzyme binding
GO:0019904 protein domain specific binding
GO:0042802 identical protein binding
GO:1990226 histone methyltransferase binding
Biological Process
GO:0006338 chromatin remodeling
GO:0006351 transcription, DNA-templated
GO:0045892 negative regulation of transcription, DNA-templated
GO:0048511 rhythmic process
Cellular Component
GO:0000779 condensed chromosome, centromeric region
GO:0000785 chromatin
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0005637 nuclear inner membrane
GO:0005719 nuclear euchromatin
GO:0005720 nuclear heterochromatin
GO:0005819 spindle
GO:0031618 nuclear centromeric heterochromatin
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000029836
View Gene Order
ENSBTAG00000005540
Not yet available
Pathways
NETPATH
REACTOME
REACT_2204
RNA Polymerase I Chain Elongation pathway
REACT_1309
RNA Polymerase I Transcription pathway
REACT_21352
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription pathway
REACT_71
Gene Expression pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.381189 Hs.713913 Hs.717386
RefSeq NM_007276 NM_016587
HUGO
OMIM
CCDS CCDS5398
HPRD 05130
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca