Version 5.4
Homo sapiens Gene: POLR3C
Summary
InnateDB Gene IDBG-101761.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol POLR3C
Gene Name polymerase (RNA) III (DNA directed) polypeptide C (62kD)
Synonyms RPC3; RPC62
Species Homo sapiens
Ensembl Gene ENSG00000186141
Encoded Proteins
IDBP-101763
polymerase (RNA) III (DNA directed) polypeptide C (62kD)
IDBP-101765
polymerase (RNA) III (DNA directed) polypeptide C (62kD)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 1:145824088-145842505
Strand Forward strand
Band q21.1
Transcripts
ENST00000334163 ENSP00000334564
ENST00000369294 ENSP00000358300
ENST00000489436
ENST00000479819
ENST00000471254
ENST00000466003
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
Experimentally validated
Total 27 [view]
Protein-Protein 27 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001056 RNA polymerase III activity
GO:0003677 DNA binding
GO:0003899 DNA-directed RNA polymerase activity
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006359 regulation of transcription from RNA polymerase III promoter
GO:0006383 transcription from RNA polymerase III promoter
GO:0006385 transcription elongation from RNA polymerase III promoter
GO:0006386 termination of RNA polymerase III transcription
GO:0010467 gene expression
GO:0032481 positive regulation of type I interferon production
GO:0032728 positive regulation of interferon-beta production
GO:0045087 innate immune response
GO:0045089 positive regulation of innate immune response
GO:0051607 defense response to virus
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005666 DNA-directed RNA polymerase III complex
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000028099
View Gene Order
ENSBTAG00000021637
Not yet available
Pathways
NETPATH
REACTOME
REACT_22339
RNA Polymerase III Abortive And Retractive Initiation pathway
REACT_63
RNA Polymerase III Transcription Termination pathway
REACT_756
RNA Polymerase III Chain Elongation pathway
REACT_571
RNA Polymerase III Transcription Initiation From Type 3 Promoter pathway
REACT_1036
RNA Polymerase III Transcription Initiation From Type 2 Promoter pathway
REACT_347
RNA Polymerase III Transcription Initiation From Type 1 Promoter pathway
REACT_281
RNA Polymerase III Transcription Initiation pathway
REACT_6802
Innate Immune System pathway
REACT_6900
Immune System pathway
REACT_1371
RNA Polymerase III Transcription pathway
REACT_21352
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription pathway
REACT_118823
Cytosolic sensors of pathogen-associated DNA pathway
REACT_71
Gene Expression pathway
KEGG
hsa00240
Pyrimidine metabolism pathway
hsa00230
Purine metabolism pathway
hsa03020
RNA polymerase pathway
hsa04623
Cytosolic DNA-sensing pathway pathway
INOH
PID NCI
Cross-References
SwissProt Q9BUI4
TrEMBL A0A024R4C1 E9PHH9
UniProt Splice Variant
Entrez Gene 10623
UniGene Hs.591457
RefSeq NM_006468 XM_005277333
HUGO HGNC:30076
OMIM
CCDS CCDS72864
HPRD
IMGT
EMBL AJ238221 AJ238222 AJ238223 AJ238224 AJ238225 AJ238226 AJ238227 AJ238228 AJ238229 AJ238230 AJ238231 AJ238232 AJ238233 AJ238234 AL160282 AY091463 BC002586 CH471244 U93867
GenPept AAB63675 AAH02586 AAM12033 CAB41919 EAW71435 EAW71436
RNA Seq Atlas 102724798 10623

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca