Version 5.4
Homo sapiens Gene: ADAMTSL4
Summary
InnateDB Gene IDBG-102129.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ADAMTSL4
Gene Name ADAMTS-like 4
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000143382
Encoded Proteins
IDBP-102131
ADAMTS-like 4
IDBP-102133
ADAMTS-like 4
IDBP-102135
ADAMTS-like 4
IDBP-102137
ADAMTS-like 4
IDBP-809287
ADAMTS-like 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs)-like gene family and encodes a protein with protein with seven thrombospondin type 1 repeats. The thrombospondin type 1 repeat domain is found in many proteins with diverse biological functions including cellular adhesion, angiogenesis, and patterning of the developing nervous system. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:150549369-150560937
Strand Forward strand
Band q21.2
Transcripts
ENST00000369041 ENSP00000358037
ENST00000271643 ENSP00000271643
ENST00000369039 ENSP00000358035
ENST00000369038 ENSP00000358034
ENST00000483335
ENST00000489159
ENST00000622417 ENSP00000477897
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
Experimentally validated
Total 31 [view]
Protein-Protein 31 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0002020 protease binding
GO:0004222 metalloendopeptidase activity
GO:0005515 protein binding
GO:0008233 peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0006915 apoptotic process
GO:0030198 extracellular matrix organization
GO:0043065 positive regulation of apoptotic process
Cellular Component
GO:0005575 cellular_component
GO:0005614 interstitial matrix
GO:0031012 extracellular matrix
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000015850
View Gene Order
ENSBTAG00000003604
Not yet available
Pathways
NETPATH
REACTOME
REACT_22161
Post-translational protein modification pathway
REACT_200727
O-linked glycosylation pathway
REACT_17015
Metabolism of proteins pathway
REACT_200626
O-glycosylation of TSR domain-containing proteins pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 54507
UniGene
RefSeq NM_001288607 NM_001288608 NM_019032 NM_025008
HUGO HGNC:19706
OMIM 610113
CCDS CCDS30852 CCDS72908 CCDS955
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas 54507

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca