InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: MCL1

Summary

InnateDB Gene

IDBG-102145.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MCL1

Gene Name

myeloid cell leukemia sequence 1 (BCL2-related)

Synonyms

bcl2-L-3; BCL2L3; EAT; Mcl-1; MCL1-ES; mcl1/EAT; MCL1L; MCL1S; TM

Species

Homo sapiens

Ensembl Gene

ENSG00000143384

Encoded Proteins

IDBP-102147

myeloid cell leukemia sequence 1 (BCL2-related)

IDBP-102149

myeloid cell leukemia sequence 1 (BCL2-related)

IDBP-809708

myeloid cell leukemia 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes an anti-apoptotic protein, which is a member of the Bcl-2 family. Alternative splicing results in multiple transcript variants. The longest gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene products (isoform 2 and isoform 3) promote apoptosis and are death-inducing. [provided by RefSeq, Oct 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:150574551-150579738

Strand

Reverse strand

Band

q21.2

Transcripts

ENST00000369026	ENSP00000358022
ENST00000307940	ENSP00000309973
ENST00000464132
ENST00000620947	ENSP00000477624

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 87 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.

Experimentally validated
Total	87 [view]
Protein-Protein	82 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	17 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0015266	protein channel activity
GO:0042803	protein homodimerization activity
GO:0046982	protein heterodimerization activity
GO:0051434	BH3 domain binding

Biological Process

GO:0001709	cell fate determination
GO:0007275	multicellular organismal development
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage
GO:0008637	apoptotic mitochondrial changes
GO:0019725	cellular homeostasis
GO:0034097	response to cytokine
GO:0042981	regulation of apoptotic process
GO:0043066	negative regulation of apoptotic process
GO:0071806	protein transmembrane transport
GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand
GO:0097194	execution phase of apoptosis
GO:1900118	negative regulation of execution phase of apoptosis
GO:2000811	negative regulation of anoikis
GO:2001020	regulation of response to DNA damage stimulus
GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:2001243	negative regulation of intrinsic apoptotic signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005741	mitochondrial outer membrane
GO:0005759	mitochondrial matrix
GO:0005829	cytosol
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0097136	Bcl-2 family protein complex

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000038612

View Gene Order

ENSBTAG00000015154

Not yet available

Pathways

NETPATH

REACTOME

KEGG

INOH

PID NCI

p53downstreampathway

Direct p53 effectors

e2f_pathway

E2F transcription factor network

hif1_tfpathway

HIF-1-alpha transcription factor network

il6_7pathway

IL6-mediated signaling events

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

4170

UniGene

RefSeq

NM_001197320 NM_021960 NM_182763

HUGO

HGNC:6943

OMIM

159552

CCDS

CCDS72909 CCDS956 CCDS957

HPRD

IMGT

EMBL

GenPept

RNA Seq Atlas

4170