Version 5.4
Homo sapiens Gene: ENSA
Summary
InnateDB Gene IDBG-102150.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ENSA
Gene Name endosulfine alpha
Synonyms ARPP-19e
Species Homo sapiens
Ensembl Gene ENSG00000143420
Encoded Proteins
IDBP-102152
endosulfine alpha
IDBP-102154
endosulfine alpha
IDBP-102156
endosulfine alpha
IDBP-102158
endosulfine alpha
IDBP-102160
endosulfine alpha
IDBP-102164
endosulfine alpha
IDBP-102168
endosulfine alpha
IDBP-102170
endosulfine alpha
IDBP-475551
endosulfine alpha
IDBP-482818
endosulfine alpha
IDBP-482866
endosulfine alpha
IDBP-474513
endosulfine alpha
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to a highly conserved cAMP-regulated phosphoprotein (ARPP) family. This protein was identified as an endogenous ligand for the sulfonylurea receptor, ABCC8/SUR1. ABCC8 is the regulatory subunit of the ATP-sensitive potassium (KATP) channel, which is located on the plasma membrane of pancreatic beta cells and plays a key role in the control of insulin release from pancreatic beta cells. This protein is thought to be an endogenous regulator of KATP channels. In vitro studies have demonstrated that this protein modulates insulin secretion through the interaction with KATP channel, and this gene has been proposed as a candidate gene for type 2 diabetes. At least eight alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:150600851-150629612
Strand Reverse strand
Band q21.3
Transcripts
ENST00000369016 ENSP00000358012
ENST00000369014 ENSP00000358010
ENST00000339643 ENSP00000341743
ENST00000361631 ENSP00000355239
ENST00000361532 ENSP00000354835
ENST00000354702
ENST00000271690 ENSP00000271690
ENST00000356527 ENSP00000348921
ENST00000362052 ENSP00000355220
ENST00000509582 ENSP00000426110
ENST00000513281 ENSP00000422343
ENST00000505321
ENST00000503345 ENSP00000421458
ENST00000503241 ENSP00000424242
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004864 protein phosphatase inhibitor activity
GO:0005102 receptor binding
GO:0008200 ion channel inhibitor activity
GO:0008601 protein phosphatase type 2A regulator activity
GO:0019212 phosphatase inhibitor activity
GO:0019870 potassium channel inhibitor activity
GO:0051721 protein phosphatase 2A binding
Biological Process
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000278 mitotic cell cycle
GO:0006810 transport
GO:0007067 mitotic nuclear division
GO:0007584 response to nutrient
GO:0009749 response to glucose
GO:0043086 negative regulation of catalytic activity
GO:0050790 regulation of catalytic activity
GO:0050796 regulation of insulin secretion
Cellular Component
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000038619
View Gene Order
ENSBTAG00000007123
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
REACT_150182
MASTL Facilitates Mitotic Progression pathway
REACT_115566
Cell Cycle pathway
REACT_910
M Phase pathway
REACT_765
Mitotic Prophase pathway
REACT_152
Cell Cycle, Mitotic pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt O43768
TrEMBL
UniProt Splice Variant
Entrez Gene 2029
UniGene Hs.602550 Hs.637149 Hs.708639
RefSeq NM_207047 NM_004436 NM_207042 NM_207043 NM_207044 NM_207045 NM_207046 NM_207168
HUGO HGNC:3360
OMIM 603061
CCDS CCDS964 CCDS958 CCDS959 CCDS960 CCDS961 CCDS962 CCDS963 CCDS965
HPRD 11927
IMGT
EMBL AF067170 AF157509 AF157510 AJ010966 AK001981 AK290064 AL356356 AY326400 AY326401 AY326402 AY326403 BC000436 BC004461 BC068544 BC069208 CH471121 CR457130 CR536578 CR749580 DA888224 X99906
GenPept AAD32454 AAF80340 AAF80341 AAH00436 AAH04461 AAH68544 AAH69208 AAQ73827 AAQ73828 AAQ73829 AAQ73830 AAQ73831 AAQ73832 BAF82753 BAG50998 CAA68180 CAB65125 CAG33411 CAG38815 CAH18372 CAI15505 CAI15506 CAI15507 CAI15509 CAI15510 CAI15511 CAI15512 EAW53528 EAW53529 EAW53530 EAW53532 EAW53533
RNA Seq Atlas 2029

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca