Version 5.4
Homo sapiens Gene: ARNT
Summary
InnateDB Gene IDBG-102199.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ARNT
Gene Name aryl hydrocarbon receptor nuclear translocator
Synonyms bHLHe2; HIF-1-beta; HIF-1beta; HIF1-beta; HIF1B; HIF1BETA; TANGO
Species Homo sapiens
Ensembl Gene ENSG00000143437
Encoded Proteins
IDBP-102205
aryl hydrocarbon receptor nuclear translocator
IDBP-102209
aryl hydrocarbon receptor nuclear translocator
IDBP-473600
aryl hydrocarbon receptor nuclear translocator
IDBP-476693
aryl hydrocarbon receptor nuclear translocator
IDBP-478032
aryl hydrocarbon receptor nuclear translocator
IDBP-475752
aryl hydrocarbon receptor nuclear translocator
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The aryl hydrocarbon (Ah) receptor is involved in the induction of several enzymes that participate in xenobiotic metabolism. The ligand-free, cytosolic form of the Ah receptor is complexed to heat shock protein 90. Binding of ligand, which includes dioxin and polycyclic aromatic hydrocarbons, results in translocation of the ligand-binding subunit only to the nucleus. Induction of enzymes involved in xenobiotic metabolism occurs through binding of the ligand-bound Ah receptor to xenobiotic responsive elements in the promoters of genes for these enzymes. This gene encodes a protein that forms a complex with the ligand-bound Ah receptor, and is required for receptor function. The encoded protein has also been identified as the beta subunit of a heterodimeric transcription factor, hypoxia-inducible factor 1. A t(1;12)(q21;p13) translocation, which results in a TEL-ARNT fusion protein, is associated with acute myeloblastic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2010]
This gene encodes a protein containing a basic helix-loop-helix domain and two characteristic PAS domains along with a PAC domain. The encoded protein binds to ligand-bound aryl hydrocarbon receptor and aids in the movement of this complex to the nucleus, where it promotes the expression of genes involved in xenobiotic metabolism. This protein is also a co-factor for transcriptional regulation by hypoxia-inducible factor 1. Chromosomal translocation of this locus with the ETV6 (ets variant 6) gene on chromosome 12 have been described in leukemias. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:150809705-150876768
Strand Reverse strand
Band q21.3
Transcripts
ENST00000354396 ENSP00000346372
ENST00000358595 ENSP00000351407
ENST00000471844 ENSP00000425899
ENST00000515192 ENSP00000423851
ENST00000505755 ENSP00000427571
ENST00000510273
ENST00000478972
ENST00000512296
ENST00000468970
ENST00000497108
ENST00000505979
ENST00000504358 ENSP00000425363
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 71 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated
Total 71 [view]
Protein-Protein 63 [view]
Protein-DNA 6 [view]
Protein-RNA 1 [view]
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000989 transcription factor binding transcription factor activity
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0003713 transcription coactivator activity
GO:0004871 signal transducer activity
GO:0004874 aryl hydrocarbon receptor activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0017162 aryl hydrocarbon receptor binding
GO:0035326 enhancer binding
GO:0043565 sequence-specific DNA binding
GO:0046982 protein heterodimerization activity
GO:0046983 protein dimerization activity
Biological Process
GO:0001666 response to hypoxia
GO:0001892 embryonic placenta development
GO:0001938 positive regulation of endothelial cell proliferation
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007165 signal transduction
GO:0010575 positive regulation vascular endothelial growth factor production
GO:0030154 cell differentiation
GO:0030522 intracellular receptor signaling pathway
GO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0033235 positive regulation of protein sumoylation
GO:0042789 mRNA transcription from RNA polymerase II promoter
GO:0043619 regulation of transcription from RNA polymerase II promoter in response to oxidative stress
GO:0045648 positive regulation of erythrocyte differentiation
GO:0045821 positive regulation of glycolytic process
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046886 positive regulation of hormone biosynthetic process
GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0071456 cellular response to hypoxia
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription factor complex
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000015522
View Gene Order
ENSBTAG00000021037
Not yet available
Pathways
NETPATH
NetPath_2
AndrogenReceptor pathway
REACTOME
REACT_121092
Regulation of gene expression by Hypoxia-inducible Factor pathway
REACT_120956
Cellular responses to stress pathway
REACT_120815
Regulation of Hypoxia-inducible Factor (HIF) by oxygen pathway
REACT_121311
Cellular response to hypoxia pathway
KEGG
hsa05211
Renal cell carcinoma pathway
hsa05200
Pathways in cancer pathway
INOH
PID NCI
hes_heypathway
Notch-mediated HES/HEY network
hif2pathway
HIF-2-alpha transcription factor network
hif1_tfpathway
HIF-1-alpha transcription factor network
hif1apathway
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.632446
RefSeq NM_001197325 NM_001286035 NM_001286036 NM_001668 NM_178427 XM_005245151 XM_005245153 XM_005245154
HUGO
OMIM
CCDS CCDS65641 CCDS65642 CCDS970 CCDS971
HPRD 00524
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca