InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: VPS72

Summary

InnateDB Gene

IDBG-102316.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

VPS72

Gene Name

vacuolar protein sorting 72 homolog (S. cerevisiae)

Synonyms

CFL1; Swc2; TCFL1; YL-1; YL1

Species

Homo sapiens

Ensembl Gene

ENSG00000163159

Encoded Proteins

IDBP-102318

vacuolar protein sorting 72 homolog (S. cerevisiae)

IDBP-102320

vacuolar protein sorting 72 homolog (S. cerevisiae)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a shared subunit of two multi-component complexes, the histone acetyltransferase complex TRRAP/TIP60 as well as the chromatin remodeling SRCAP-containing complex. The TRRAP/TIP60 complex acetylates nucleosomal histones important for transcriptional regulation, double strand DNA break repair and apoptosis. The SRCAP-containing complex catalyzes the exchange of histone H2A with the histone variant Htz1 (H2AFZ) into nucleosomes. This protein may be responsible for binding H2AFZ, which has a role in chromosome segregation. This protein may also have a role in regulating long-term hematopoietic stem cell activity. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Aug 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:151169987-151195321

Strand

Reverse strand

Band

q21.3

Transcripts

ENST00000368892	ENSP00000357887
ENST00000354473	ENSP00000346464
ENST00000491094
ENST00000496809
ENST00000471423
ENST00000463470

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	23 [view]
Protein-Protein	21 [view]
Protein-DNA	1 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006325	chromatin organization
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0016568	chromatin modification
GO:0035019	somatic stem cell maintenance

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0043234	protein complex

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000008958

View Gene Order

ENSBTAG00000018074

Not yet available

Pathways

NETPATH

REACTOME

REACT_172610

HATs acetylate histones pathway

REACT_172623

Chromatin organization pathway

REACT_172633

Chromatin modifying enzymes pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

Q15906

TrEMBL

UniProt Splice Variant

Entrez Gene

6944

UniGene

RefSeq

NM_001271087 NM_001271088 NM_005997

HUGO

HGNC:11644

OMIM

600607

CCDS

CCDS59201 CCDS989

HPRD

02791

IMGT

EMBL

AK222935 AK222939 AL592424 BC003151 BT019356 BT019357 CH471121 CX163016 D43642

GenPept

AAH03151 AAV38163 AAV38164 BAA07757 BAD96655 BAD96659 CAI16385 EAW53462

RNA Seq Atlas

6944