InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: S100A10

Summary

InnateDB Gene

IDBG-102454.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

S100A10

Gene Name

S100 calcium binding protein A10

Synonyms

42C; ANX2L; ANX2LG; Ca[1]; CAL1L; CLP11; GP11; p10; P11

Species

Homo sapiens

Ensembl Gene

ENSG00000197747

Encoded Proteins

IDBP-102456

S100 calcium binding protein A10

IDBP-102458

S100 calcium binding protein A10

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21115493

S100A10 :: ANXA2 is a key profibrinolytic complex that assembles plasminogen and tissue plasminogen activator, and promotes plasmin generation. As a negative feedback regulation, plasmin can induce disassociation of the heterotetramer and ubiquitin-mediated degradation of S100A10.

InnateDB Annotation from Orthologs

Summary

PMID 21115493

[Mus musculus] S100a10 :: Anxa2 is a key profibrinolytic complex that assembles plasminogen and tissue plasminogen activator, and promotes plasmin generation. As a negative feedback regulation, plasmin can induce disassociation of the heterotetramer and ubiquitin-mediated degradation of S100a10.

Entrez Gene

Summary

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in exocytosis and endocytosis. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:151982915-151994390

Strand

Reverse strand

Band

q21.3

Transcripts

ENST00000368811	ENSP00000357801
ENST00000368809	ENSP00000357799
ENST00000478574
ENST00000478348

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 41 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	41 [view]
Protein-Protein	41 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0042803	protein homodimerization activity
GO:0044325	ion channel binding

Biological Process

GO:0001765	membrane raft assembly
GO:0006900	membrane budding
GO:0032855	positive regulation of Rac GTPase activity
GO:0045087	innate immune response (InnateDB)
GO:0051099	positive regulation of binding
GO:0051290	protein heterotetramerization
GO:0051496	positive regulation of stress fiber assembly
GO:0051894	positive regulation of focal adhesion assembly
GO:0071229	cellular response to acid
GO:0090002	establishment of protein localization to plasma membrane
GO:1900026	positive regulation of substrate adhesion-dependent cell spreading

Cellular Component

GO:0019897	extrinsic component of plasma membrane
GO:0045121	membrane raft
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000041959

View Gene Order

ENSBTAG00000015147

Not yet available

Pathways

NETPATH

NetPath_4

EGFR1 pathway

REACTOME

REACT_641

Dissolution of Fibrin Clot pathway

REACT_15518

Transmembrane transport of small molecules pathway

REACT_267716

Orphan transporters pathway

REACT_604

Hemostasis pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.608420

RefSeq

NM_002966

HUGO

OMIM

CCDS

CCDS1008

HPRD

00232

IMGT

EMBL

GenPept

RNA Seq Atlas