Homo sapiens Gene: LOR
Summary
InnateDB Gene IDBG-102633.5
Last Modified 2012-02-14 [Report errors or provide feedback]
Gene Symbol LOR
Gene Name loricrin
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000203782
Encoded Proteins
loricrin
Protein Structure
Entrez Gene
Summary This gene encodes loricrin, a major protein component of the cornified cell envelope found in terminally differentiated epidermal cells. Mutations in this gene are associated with Vohwinkel's syndrome and progressive symmetric erythrokeratoderma, both inherited skin diseases. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:153232176-153234598
Strand Forward strand
Band q21.3
Transcripts
ENST00000368742 ENSP00000357731
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005198 structural molecule activity
GO:0005200 structural constituent of cytoskeleton
GO:0005515 protein binding
GO:0030280 structural constituent of epidermis
GO:0030674 protein binding, bridging
Biological Process
GO:0018149 peptide cross-linking
GO:0030216 keratinocyte differentiation
GO:0031424 keratinization
Cellular Component
GO:0001533 cornified envelope
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0009898 internal side of plasma membrane
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Cross-References
SwissProt P23490
TrEMBL Q6FHY3
UniProt Splice Variant
Entrez Gene 4014
UniGene Hs.251680
RefSeq NM_000427
HUGO 6663
OMIM 152445
CCDS CCDS30870
HPRD 01070
IMGT
EMBL AL161636 BC034690 BC108290 CR536555 M61120 M94077
GenPept AAA36180 AAA36181 AAH34690 AAI08291 CAG38792 CAI19560
ImmGen LOR (murine)
RNA Seq Atlas 4014