Version 5.4
Homo sapiens Gene: ZBTB7B
Summary
InnateDB Gene IDBG-103049.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ZBTB7B
Gene Name zinc finger and BTB domain containing 7B
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000160685
Encoded Proteins
IDBP-103051
zinc finger and BTB domain containing 7B
IDBP-103053
zinc finger and BTB domain containing 7B
IDBP-388792
zinc finger and BTB domain containing 7B
IDBP-594383
zinc finger and BTB domain containing 7B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a zinc finger-containing transcription factor that acts as a key regulator of lineage commitment of immature T-cell precursors. It is necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. It also functions as a transcriptional repressor of type I collagen genes. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:155002630-155018522
Strand Forward strand
Band q21.3
Transcripts
ENST00000368426 ENSP00000357411
ENST00000292176 ENSP00000292176
ENST00000417934 ENSP00000406286
ENST00000487542
ENST00000461530
ENST00000483226
ENST00000535420 ENSP00000438647
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 29 [view]
Protein-Protein 25 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0007275 multicellular organismal development
GO:0007398 ectoderm development
GO:0010628 positive regulation of gene expression
GO:0030154 cell differentiation
GO:0043370 regulation of CD4-positive, alpha-beta T cell differentiation
GO:0043376 regulation of CD8-positive, alpha-beta T cell differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000028042
View Gene Order
ENSBTAG00000021512
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.729279 Hs.736325
RefSeq NM_001252406 NM_001256455 XM_006711349 XM_006711351 XM_006711352 XM_006711353 XM_006711354 XM_006711355 XM_006711356 XM_006711357 XM_006711358 XM_006711359
HUGO
OMIM
CCDS CCDS1081 CCDS58030
HPRD 09625
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca