Version 5.4
Homo sapiens Gene: THBS3
Summary
InnateDB Gene IDBG-103178.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol THBS3
Gene Name thrombospondin 3
Synonyms TSP3
Species Homo sapiens
Ensembl Gene ENSG00000169231
Encoded Proteins
IDBP-103180
thrombospondin 3
IDBP-372559
thrombospondin 3
IDBP-388872
thrombospondin 3
IDBP-596864
thrombospondin 3
IDBP-600873
thrombospondin 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the thrombospondin family. Thrombospondin family members are adhesive glycoproteins that mediate cell-to-cell and cell-to-matrix interactions. This protein forms a pentameric molecule linked by a single disulfide bond. This gene shares a common promoter with metaxin 1. Alternate splicing results in coding and non-coding transcript variants. [provided by RefSeq, Nov 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:155195588-155209051
Strand Reverse strand
Band q22
Transcripts
ENST00000368378 ENSP00000357362
ENST00000428962 ENSP00000404040
ENST00000457183 ENSP00000392207
ENST00000498500
ENST00000469769
ENST00000465596
ENST00000486260
ENST00000496332
ENST00000460050
ENST00000541990 ENSP00000437353
ENST00000541576 ENSP00000444792
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0008201 heparin binding
Biological Process
GO:0003417 growth plate cartilage development
GO:0007155 cell adhesion
GO:0007160 cell-matrix adhesion
GO:0043931 ossification involved in bone maturation
GO:0060346 bone trabecula formation
Cellular Component
GO:0005576 extracellular region
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000028047
View Gene Order
ENSBTAG00000000057
Not yet available
Pathways
NETPATH
REACTOME
REACT_16888
Signaling by PDGF pathway
REACT_111102
Signal Transduction pathway
KEGG
hsa04512
ECM-receptor interaction pathway
hsa04510
Focal adhesion pathway
hsa05144
Malaria pathway
hsa04145
Phagosome pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL F5H4Z8 Q2HIZ1
UniProt Splice Variant
Entrez Gene 7059
UniGene Hs.169875 Hs.734015
RefSeq NM_001252607 NM_001252608 NM_007112 XM_006711498 XM_006711499 XM_006711500 XM_006711502
HUGO HGNC:11787
OMIM 188062
CCDS CCDS72937 CCDS1099 CCDS58034
HPRD 01767
IMGT
EMBL AL713999 BC113846
GenPept AAI13847
RNA Seq Atlas 7059

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca