Version 5.4
Homo sapiens Gene: PKLR
Summary
InnateDB Gene IDBG-103234.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PKLR
Gene Name pyruvate kinase, liver and RBC
Synonyms PK1; PKL; PKR; PKRL; RPK
Species Homo sapiens
Ensembl Gene ENSG00000143627
Encoded Proteins
IDBP-103236
pyruvate kinase, liver and RBC
IDBP-245715
pyruvate kinase, liver and RBC
IDBP-388910
pyruvate kinase, liver and RBC
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 22022264
PKLR is recruited by hepatitis C virus early in infection as a sensor to trigger the induction of IRF3-dependent genes.
InnateDB Annotation from Orthologs
Summary
PMID 22022264
[Mus musculus] Pklr is recruited by hepatitis C virus early in infection as a sensor to trigger the induction of Irf3-dependent genes. (Demonstrated in human)
Entrez Gene
Summary The protein encoded by this gene is a pyruvate kinase that catalyzes the transphosphorylation of phohsphoenolpyruvate into pyruvate and ATP, which is the rate-limiting step of glycolysis. Defects in this enzyme, due to gene mutations or genetic variations, are the common cause of chronic hereditary nonspherocytic hemolytic anemia (CNSHA or HNSHA). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:155289839-155301434
Strand Reverse strand
Band q22
Transcripts
ENST00000342741 ENSP00000339933
ENST00000392414 ENSP00000376214
ENST00000434082 ENSP00000398037
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 14 [view]
Protein-Protein 14 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0003824 catalytic activity
GO:0004743 pyruvate kinase activity
GO:0005524 ATP binding
GO:0030955 potassium ion binding
Biological Process
GO:0001666 response to hypoxia
GO:0005975 carbohydrate metabolic process
GO:0006006 glucose metabolic process
GO:0006096 glycolytic process
GO:0006112 energy reserve metabolic process
GO:0006754 ATP biosynthetic process
GO:0007584 response to nutrient
GO:0009408 response to heat
GO:0009749 response to glucose
GO:0010038 response to metal ion
GO:0010226 response to lithium ion
GO:0014070 response to organic cyclic compound
GO:0016310 phosphorylation
GO:0031018 endocrine pancreas development
GO:0031325 positive regulation of cellular metabolic process
GO:0032869 cellular response to insulin stimulus
GO:0033198 response to ATP
GO:0042866 pyruvate biosynthetic process
GO:0044281 small molecule metabolic process
GO:0045087 innate immune response (InnateDB)
GO:0051591 response to cAMP
GO:0051707 response to other organism
Cellular Component
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000041237
View Gene Order
ENSBTAG00000017056
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa00010
Glycolysis / Gluconeogenesis pathway
hsa00620
Pyruvate metabolism pathway
hsa00230
Purine metabolism pathway
hsa04910
Insulin signaling pathway pathway
hsa04950
Maturity onset diabetes of the young pathway
hsa04930
Type II diabetes mellitus pathway
INOH
INOH website
Purine nucleotides nucleosides metabolism pathway
INOH website
Glycolysis Gluconeogenesis pathway
PID NCI
hnf3bpathway
FOXA2 and FOXA3 transcription factor networks
Cross-References
SwissProt P30613
TrEMBL B4DPM0 Q16716
UniProt Splice Variant
Entrez Gene 5313
UniGene Hs.670128 Hs.95990
RefSeq NM_181871 XM_005245266 XM_006711386 XM_006726212 NM_000298
HUGO HGNC:9020
OMIM 609712
CCDS CCDS44240 CCDS1109
HPRD 11841
IMGT
EMBL AB015983 AK298399 AY316591 BC025737 M15465 S60712 U47654
GenPept AAA60104 AAA92536 AAB26262 AAH25737 AAP69527 BAA31706 BAG60632
RNA Seq Atlas 5313

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca