Version 5.4
Homo sapiens Gene: HOXA2
Summary
InnateDB Gene IDBG-10335.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HOXA2
Gene Name homeobox A2
Synonyms HOX1K; MCOHI
Species Homo sapiens
Ensembl Gene ENSG00000105996
Encoded Proteins
IDBP-10337
homeobox A2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. The encoded protein may be involved in the placement of hindbrain segments in the proper location along the anterior-posterior axis during development. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:27100354-27102811
Strand Reverse strand
Band p15.2
Transcripts
ENST00000222718 ENSP00000222718
ENST00000612779
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 8 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001709 cell fate determination
GO:0002076 osteoblast development
GO:0006351 transcription, DNA-templated
GO:0007379 segment specification
GO:0007389 pattern specification process
GO:0008045 motor neuron axon guidance
GO:0009952 anterior/posterior pattern specification
GO:0009953 dorsal/ventral pattern formation
GO:0021568 rhombomere 2 development
GO:0021569 rhombomere 3 development
GO:0021658 rhombomere 3 morphogenesis
GO:0035284 brain segmentation
GO:0042474 middle ear morphogenesis
GO:0045165 cell fate commitment
GO:0045665 negative regulation of neuron differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048703 embryonic viscerocranium morphogenesis
GO:0048704 embryonic skeletal system morphogenesis
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000014704
View Gene Order
ENSBTAG00000008138
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.592177 Hs.614894
RefSeq NM_006735
HUGO
OMIM
CCDS CCDS5403
HPRD 05252
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca