Version 5.4
Homo sapiens Gene: LAMTOR2
Summary
InnateDB Gene IDBG-103365.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LAMTOR2
Gene Name late endosomal/lysosomal adaptor, MAPK and MTOR activator 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000116586
Encoded Proteins
IDBP-103367
late endosomal/lysosomal adaptor, MAPK and MTOR activator 2
IDBP-103369
late endosomal/lysosomal adaptor, MAPK and MTOR activator 2
IDBP-103371
late endosomal/lysosomal adaptor, MAPK and MTOR activator 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The product of this gene is highly conserved with a mouse protein associated with the cytoplasmic face of late endosomes and lysosomes. The mouse protein interacts with MAPK scaffold protein 1, a component of the mitogen-activated protein kinase pathway. In humans, a mutation in this gene has been associated with a primary immunodeficiency syndrome, and suggests a role for this protein in endosomal biogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:156054752-156058510
Strand Forward strand
Band q22
Transcripts
ENST00000368305 ENSP00000357288
ENST00000368304 ENSP00000357287
ENST00000368302 ENSP00000357285
ENST00000489664
ENST00000487106
ENST00000463371
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 16 [view]
Protein-Protein 15 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0032947 protein complex scaffold
Biological Process
GO:0000186 activation of MAPKK activity
GO:0016049 cell growth
GO:0032008 positive regulation of TOR signaling
GO:0034613 cellular protein localization
GO:0043547 positive regulation of GTPase activity
GO:0071230 cellular response to amino acid stimulus
Cellular Component
GO:0005765 lysosomal membrane
GO:0005770 late endosome
GO:0070062 extracellular vesicular exosome
GO:0071986 Ragulator complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000028062
View Gene Order
ENSBTAG00000011754
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001145264 NM_014017
HUGO
OMIM
CCDS CCDS1128 CCDS44243
HPRD 17463
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca