InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CCT3

Summary

InnateDB Gene

IDBG-103469.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CCT3

Gene Name

chaperonin containing TCP1, subunit 3 (gamma)

Synonyms

CCT-gamma; CCTG; PIG48; TCP-1-gamma; TRIC5

Species

Homo sapiens

Ensembl Gene

ENSG00000163468

Encoded Proteins

IDBP-103471

chaperonin containing TCP1, subunit 3 (gamma)

IDBP-103477

chaperonin containing TCP1, subunit 3 (gamma)

IDBP-103479

chaperonin containing TCP1, subunit 3 (gamma)

IDBP-103481

chaperonin containing TCP1, subunit 3 (gamma)

IDBP-389079

chaperonin containing TCP1, subunit 3 (gamma)

IDBP-389080

chaperonin containing TCP1, subunit 3 (gamma)

IDBP-389081

chaperonin containing TCP1, subunit 3 (gamma)

IDBP-601334

chaperonin containing TCP1, subunit 3 (gamma)

IDBP-599970

chaperonin containing TCP1, subunit 3 (gamma)

IDBP-585620

chaperonin containing TCP1, subunit 3 (gamma)

IDBP-600991

chaperonin containing TCP1, subunit 3 (gamma)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants have been characterized for this gene. In addition, a pseudogene of this gene has been found on chromosome 8. [provided by RefSeq, Aug 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:156308968-156367873

Strand

Reverse strand

Band

q22

Transcripts

ENST00000368262	ENSP00000357245
ENST00000368261
ENST00000368259	ENSP00000357242
ENST00000368258	ENSP00000357241
ENST00000295688	ENSP00000295688
ENST00000368256
ENST00000413555	ENSP00000413308
ENST00000446905	ENSP00000388799
ENST00000415548	ENSP00000413431
ENST00000472765	ENSP00000431543
ENST00000496684	ENSP00000434232
ENST00000463132
ENST00000490221
ENST00000478640	ENSP00000435026
ENST00000489870
ENST00000533194	ENSP00000434481

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 136 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	136 [view]
Protein-Protein	136 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0044822	poly(A) RNA binding
GO:0051082	unfolded protein binding

Biological Process

GO:0006457	protein folding
GO:0007339	binding of sperm to zona pellucida
GO:0044267	cellular protein metabolic process
GO:0051084	'de novo' posttranslational protein folding

Cellular Component

GO:0002199	zona pellucida receptor complex
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005832	chaperonin-containing T-complex
GO:0005856	cytoskeleton
GO:0005874	microtubule
GO:0005886	plasma membrane
GO:0044297	cell body
GO:0070062	extracellular vesicular exosome