InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ABCA3

Summary

InnateDB Gene

IDBG-10371.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ABCA3

Gene Name

ATP-binding cassette, sub-family A (ABC1), member 3

Synonyms

ABC-C; ABC3; EST111653; LBM180; SMDP3

Species

Homo sapiens

Ensembl Gene

ENSG00000167972

Encoded Proteins

IDBP-10373

ATP-binding cassette, sub-family A (ABC1), member 3

IDBP-10377

ATP-binding cassette, sub-family A (ABC1), member 3

IDBP-750933

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. The full transporter encoded by this gene may be involved in development of resistance to xenobiotics and engulfment during programmed cell death. [provided by RefSeq, Jul 2008]
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. The full transporter encoded by this gene may be involved in development of resistance to xenobiotics and engulfment during programmed cell death. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:2275881-2340746

Strand

Reverse strand

Band

p13.3

Transcripts

ENST00000382381	ENSP00000371818
ENST00000301732	ENSP00000301732
ENST00000563623
ENST00000566200
ENST00000567910	ENSP00000454397
ENST00000569062

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	3 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0005524	ATP binding
GO:0016887	ATPase activity
GO:0042626	ATPase activity, coupled to transmembrane movement of substances

Biological Process

GO:0006200	ATP catabolic process
GO:0006810	transport
GO:0042493	response to drug
GO:0055085	transmembrane transport

Cellular Component

GO:0005615	extracellular space
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0097208	alveolar lamellar body
GO:0097233	alveolar lamellar body membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000024130

View Gene Order

ENSBTAG00000014903

Not yet available

Pathways

NETPATH

REACTOME

REACT_111158

ABCA transporters in lipid homeostasis pathway

REACT_15480

ABC-family proteins mediated transport pathway

REACT_15518

Transmembrane transport of small molecules pathway

KEGG

hsa02010

ABC transporters pathway

INOH

PID NCI

era_genomic_pathway

Validated nuclear estrogen receptor alpha network

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.26630

RefSeq

NM_001089

HUGO

OMIM

CCDS

CCDS10466

HPRD

03369

IMGT

EMBL

GenPept

RNA Seq Atlas