Version 5.4
| Homo sapiens Gene: PYHIN1 | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-103841.6 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | PYHIN1 | ||||||||||||||||||
| Gene Name | pyrin and HIN domain family, member 1 | ||||||||||||||||||
| Synonyms | |||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Gene | ENSG00000163564 | ||||||||||||||||||
| Encoded Proteins |
pyrin and HIN domain family, member 1
pyrin and HIN domain family, member 1
pyrin and HIN domain family, member 1
pyrin and HIN domain family, member 1
pyrin and HIN domain family, member 1
pyrin and HIN domain family, member 1
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| Protein Structure | |||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| Summary |
The protein encoded by this gene belongs to the HIN-200 family of interferon-inducible proteins that share a 200-amino acid signature motif at their C-termini. HIN200 proteins are primarily nuclear and are involved in transcriptional regulation of genes important for cell cycle control, differentiation, and apoptosis. Downregulation of this gene is associated with breast cancer. This protein acts as a tumor suppressor by promoting ubiquitination and subsequent degradation of MDM2, which leads to stabilization of p53/TP53. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 1:158930796-158977054 | ||||||||||||||||||
| Strand | Forward strand | ||||||||||||||||||
| Band | q23.1 | ||||||||||||||||||
| Transcripts | |||||||||||||||||||
| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
| No orthologs found for this gene | |||||||||||||||||||
| Cross-References | |||||||||||||||||||
| SwissProt | |||||||||||||||||||
| TrEMBL | X6RHR0 | ||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | 149628 | ||||||||||||||||||
| UniGene | Hs.734876 | ||||||||||||||||||
| RefSeq | NM_152501 NM_198928 NM_198929 NM_198930 XM_005244930 XM_006711191 | ||||||||||||||||||
| HUGO | HGNC:28894 | ||||||||||||||||||
| OMIM | 612677 | ||||||||||||||||||
| CCDS | CCDS1178 CCDS1179 CCDS30907 CCDS30908 | ||||||||||||||||||
| HPRD | 09999 | ||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | AL359753 | ||||||||||||||||||
| GenPept | |||||||||||||||||||
| RNA Seq Atlas | 149628 | ||||||||||||||||||