Version 5.4
| Homo sapiens Gene: SLAMF6 | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-104051.6 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | SLAMF6 | ||||||||||||||||||
| Gene Name | SLAM family member 6 | ||||||||||||||||||
| Synonyms | |||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Gene | ENSG00000162739 | ||||||||||||||||||
| Encoded Proteins |
SLAM family member 6
SLAM family member 6
SLAM family member 6
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| InnateDB Annotation | |||||||||||||||||||
| Summary |
The SLAM and SAP gene families control innate and adaptive immune responses
SLAM receptors and SAP influence lymphocyte interactions, development and function
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| Entrez Gene | |||||||||||||||||||
| Summary |
The protein encoded by this gene is a type I transmembrane protein, belonging to the CD2 subfamily of the immunoglobulin superfamily. This encoded protein is expressed on Natural killer (NK), T, and B lymphocytes. It undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases (SHPs). It functions as a coreceptor in the process of NK cell activation. It can also mediate inhibitory signals in NK cells from X-linked lymphoproliferative patients. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, May 2010] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 1:160485030-160523262 | ||||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||||
| Band | q23.3 | ||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
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Species
Mus musculus
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Gene ID
Gene Order
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| Pathways | |||||||||||||||||||
| NETPATH |
TCR pathway
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| REACTOME | |||||||||||||||||||
| KEGG | |||||||||||||||||||
| INOH | |||||||||||||||||||
| PID NCI | |||||||||||||||||||
| Cross-References | |||||||||||||||||||
| SwissProt | Q96DU3 | ||||||||||||||||||
| TrEMBL | |||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | 114836 | ||||||||||||||||||
| UniGene | Hs.492348 | ||||||||||||||||||
| RefSeq | NM_001184714 NM_001184715 NM_001184716 NM_052931 | ||||||||||||||||||
| HUGO | HGNC:21392 | ||||||||||||||||||
| OMIM | 606446 | ||||||||||||||||||
| CCDS | CCDS1205 CCDS53393 CCDS53394 | ||||||||||||||||||
| HPRD | |||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | AJ277141 AJ306388 AK125624 AK301026 AK313549 AL138930 AL832854 AY358159 BC113893 BC114495 CH471121 | ||||||||||||||||||
| GenPept | AAI13894 AAI14496 AAQ88526 BAG36325 BAG54223 BAG62642 CAC59749 CAC59750 CAI15155 CAI15156 CAI15157 CAI46161 EAW52713 EAW52715 | ||||||||||||||||||
| RNA Seq Atlas | 114836 | ||||||||||||||||||