Version 5.4
Homo sapiens Gene: DEDD
Summary
InnateDB Gene IDBG-104188.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DEDD
Gene Name death effector domain containing
Synonyms CASP8IP1; DEDD1; DEFT; FLDED1
Species Homo sapiens
Ensembl Gene ENSG00000158796
Encoded Proteins
IDBP-104190
death effector domain containing
IDBP-104192
death effector domain containing
IDBP-389321
death effector domain containing
IDBP-811101
death effector domain containing
IDBP-811097
death effector domain containing
IDBP-586880
death effector domain containing
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein that contains a death effector domain (DED). DED is a protein-protein interaction domain shared by adaptors, regulators and executors of the programmed cell death pathway. Overexpression of this gene was shown to induce weak apoptosis. Upon stimulation, this protein was found to translocate from cytoplasm to nucleus and colocalize with UBTF, a basal factor required for RNA polymerase I transcription, in the nucleolus. At least three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:161120974-161132688
Strand Reverse strand
Band q23.3
Transcripts
ENST00000368006 ENSP00000356985
ENST00000368005 ENSP00000356984
ENST00000458050 ENSP00000414821
ENST00000472996
ENST00000489249
ENST00000486041
ENST00000464113 ENSP00000476316
ENST00000473679
ENST00000490843 ENSP00000476946
ENST00000463227
ENST00000496632
ENST00000545495 ENSP00000445835
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 34 [view]
Protein-Protein 32 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0007283 spermatogenesis
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors
GO:0042177 negative regulation of protein catabolic process
GO:0042981 regulation of apoptotic process
GO:0046697 decidualization
GO:1901837 negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter
Cellular Component
GO:0005730 nucleolus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000013973
View Gene Order
ENSBTAG00000020154
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
p73pathway
p73 transcription factor network
Cross-References
SwissProt
TrEMBL B1AQP5
UniProt Splice Variant
Entrez Gene 9191
UniGene Hs.146406 Hs.727157
RefSeq XM_005245597 XM_005245598 XM_005245599 XM_005245600 NM_001039711 NM_001039712 NM_032998
HUGO HGNC:2755
OMIM 606841
CCDS CCDS1219
HPRD 06022
IMGT
EMBL AL591806 CH471121
GenPept EAW52649
RNA Seq Atlas 9191

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca