Version 5.4
Homo sapiens Gene: NR1I3
Summary
InnateDB Gene IDBG-104246.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NR1I3
Gene Name nuclear receptor subfamily 1, group I, member 3
Synonyms CAR; CAR1; MB67
Species Homo sapiens
Ensembl Gene ENSG00000143257
Encoded Proteins
IDBP-104248
nuclear receptor subfamily 1, group I, member 3
IDBP-104250
nuclear receptor subfamily 1, group I, member 3
IDBP-104252
nuclear receptor subfamily 1, group I, member 3
IDBP-104254
nuclear receptor subfamily 1, group I, member 3
IDBP-104256
nuclear receptor subfamily 1, group I, member 3
IDBP-104258
nuclear receptor subfamily 1, group I, member 3
IDBP-104260
nuclear receptor subfamily 1, group I, member 3
IDBP-389369
nuclear receptor subfamily 1, group I, member 3
IDBP-389370
nuclear receptor subfamily 1, group I, member 3
IDBP-389372
nuclear receptor subfamily 1, group I, member 3
IDBP-389373
nuclear receptor subfamily 1, group I, member 3
IDBP-484131
nuclear receptor subfamily 1, group I, member 3
IDBP-484416
nuclear receptor subfamily 1, group I, member 3
IDBP-480490
nuclear receptor subfamily 1, group I, member 3
IDBP-481714
nuclear receptor subfamily 1, group I, member 3
IDBP-476848
nuclear receptor subfamily 1, group I, member 3
IDBP-485155
nuclear receptor subfamily 1, group I, member 3
IDBP-479904
nuclear receptor subfamily 1, group I, member 3
IDBP-480624
nuclear receptor subfamily 1, group I, member 3
IDBP-482098
nuclear receptor subfamily 1, group I, member 3
IDBP-483559
nuclear receptor subfamily 1, group I, member 3
IDBP-473992
nuclear receptor subfamily 1, group I, member 3
IDBP-481161
nuclear receptor subfamily 1, group I, member 3
IDBP-484755
nuclear receptor subfamily 1, group I, member 3
IDBP-481162
nuclear receptor subfamily 1, group I, member 3
IDBP-484191
nuclear receptor subfamily 1, group I, member 3
IDBP-476919
nuclear receptor subfamily 1, group I, member 3
IDBP-474780
nuclear receptor subfamily 1, group I, member 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:161229666-161238302
Strand Reverse strand
Band q23.3
Transcripts
ENST00000367985 ENSP00000356965
ENST00000367983 ENSP00000356962
ENST00000367984 ENSP00000356963
ENST00000367982 ENSP00000356961
ENST00000367981 ENSP00000356960
ENST00000367980 ENSP00000356959
ENST00000367979 ENSP00000356958
ENST00000428574 ENSP00000412672
ENST00000442691 ENSP00000406493
ENST00000412844 ENSP00000399361
ENST00000437437 ENSP00000407446
ENST00000512372 ENSP00000425417
ENST00000488651
ENST00000464422
ENST00000479324
ENST00000505005 ENSP00000424934
ENST00000508740 ENSP00000423666
ENST00000506018 ENSP00000424834
ENST00000508387 ENSP00000422982
ENST00000504010 ENSP00000424345
ENST00000511676 ENSP00000427175
ENST00000502985 ENSP00000421374
ENST00000512340 ENSP00000423007
ENST00000510951 ENSP00000425607
ENST00000502848 ENSP00000426016
ENST00000515621 ENSP00000421588
ENST00000507215 ENSP00000425900
ENST00000511944 ENSP00000426292
ENST00000511748 ENSP00000427600
ENST00000506209 ENSP00000423089
ENST00000505944
ENST00000515452 ENSP00000427034
ENST00000503547
ENST00000491193
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 18 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding
GO:0001228 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003707 steroid hormone receptor activity
GO:0003713 transcription coactivator activity
GO:0004879 ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0004882 androgen receptor activity
GO:0004887 thyroid hormone receptor activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0007165 signal transduction
GO:0010467 gene expression
GO:0030521 androgen receptor signaling pathway
GO:0030522 intracellular receptor signaling pathway
GO:0043401 steroid hormone mediated signaling pathway
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000005677
View Gene Order
ENSBTAG00000009215
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
reg_gr_pathway
Glucocorticoid receptor regulatory network
Cross-References
SwissProt
TrEMBL Q6GZ72
UniProt Splice Variant
Entrez Gene 9970
UniGene Hs.349642
RefSeq NM_001077469 NM_001077470 NM_001077471 NM_001077472 NM_001077473 NM_001077474 NM_001077475 NM_001077476 NM_001077477 NM_001077478 NM_001077479 NM_001077480 NM_001077481 NM_001077482 NM_005122 XM_005245693 XM_005245694 XM_005245697 XM_006711696
HUGO HGNC:7969
OMIM 603881
CCDS CCDS1228 CCDS41427 CCDS41428 CCDS41429 CCDS41430 CCDS44260 CCDS44261 CCDS44262 CCDS53405 CCDS53406 CCDS53407 CCDS53408 CCDS53409 CCDS53410 CCDS53411
HPRD 04858
IMGT
EMBL AL590714 AY572822 AY572823
GenPept AAT47175 AAT47176
RNA Seq Atlas 9970

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca