Version 5.4
| Homo sapiens Gene: FCGR2A | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-104282.6 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | FCGR2A | ||||||||||||||||||
| Gene Name | Fc fragment of IgG, low affinity IIa, receptor (CD32) | ||||||||||||||||||
| Synonyms | CD32; CD32A; CDw32; FCG2; FcGR; FCGR2; FCGR2A1; IGFR2 | ||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Gene | ENSG00000143226 | ||||||||||||||||||
| Encoded Proteins |
Fc fragment of IgG, low affinity IIa, receptor (CD32)
Fc fragment of IgG, low affinity IIa, receptor (CD32)
Fc fragment of IgG, low affinity IIa, receptor (CD32)
Fc fragment of IgG, low affinity IIa, receptor (CD32)
Fc fragment of IgG, low affinity IIa, receptor (CD32)
Fc fragment of IgG, low affinity IIa, receptor (CD32)
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| Protein Structure | |||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| InnateDB Annotation | |||||||||||||||||||
| Summary |
FCGR2A is a receptor for immunoglobulin G, clustering induces shape change, secretion and aggregation
FCGR2A (FcgammaRIIA) is a receptor that recognizes IgG opsonized particles and initiates phagocytosis in immune clearance. FCGR2A is also a positive regulator of complement-mediated phagocytosis.
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| Entrez Gene | |||||||||||||||||||
| Summary |
This gene encodes one member of a family of immunoglobulin Fc receptor genes found on the surface of many immune response cells. The protein encoded by this gene is a cell surface receptor found on phagocytic cells such as macrophages and neutrophils, and is involved in the process of phagocytosis and clearing of immune complexes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2008] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 1:161505430-161524013 | ||||||||||||||||||
| Strand | Forward strand | ||||||||||||||||||
| Band | q23.3 | ||||||||||||||||||
| Transcripts | |||||||||||||||||||
| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
| No orthologs found for this gene | |||||||||||||||||||
| Pathways | |||||||||||||||||||
| NETPATH | |||||||||||||||||||
| REACTOME |
Regulation of actin dynamics for phagocytic cup formation pathway
Role of phospholipids in phagocytosis pathway
FCGR activation pathway
Innate Immune System pathway
Immune System pathway
Fcgamma receptor (FCGR) dependent phagocytosis pathway
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| KEGG |
Systemic lupus erythematosus pathway
Fc gamma R-mediated phagocytosis pathway
Leishmaniasis pathway
Staphylococcus aureus infection pathway
Osteoclast differentiation pathway
Phagosome pathway
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| INOH | |||||||||||||||||||
| PID NCI |
Beta2 integrin cell surface interactions
Signaling events mediated by PTP1B
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| Cross-References | |||||||||||||||||||
| SwissProt | |||||||||||||||||||
| TrEMBL | |||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| UniGene | Hs.352642 Hs.656750 Hs.691115 Hs.717076 | ||||||||||||||||||
| RefSeq | NM_001136219 NM_021642 NM_201563 | ||||||||||||||||||
| HUGO | |||||||||||||||||||
| OMIM | |||||||||||||||||||
| CCDS | CCDS30922 CCDS44264 | ||||||||||||||||||
| HPRD | 00906 | ||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | |||||||||||||||||||
| GenPept | |||||||||||||||||||
| RNA Seq Atlas | |||||||||||||||||||