Homo sapiens Gene: FCGR3A | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Gene | IDBG-104292.6 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | FCGR3A | ||||||||||||||||||
Gene Name | Fc fragment of IgG, low affinity IIIa, receptor (CD16a) | ||||||||||||||||||
Synonyms | CD16; CD16A; FCG3; FCGR3; FCGRIII; FCR-10; FCRIII; FCRIIIA; IGFR3; IMD20 | ||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||
Ensembl Gene | ENSG00000203747 | ||||||||||||||||||
Encoded Proteins |
Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
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Protein Structure | |||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
Entrez Gene | |||||||||||||||||||
Summary |
This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other other antibody-dependent responses. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||
Type | Protein coding | ||||||||||||||||||
Genomic Location | Chromosome 1:161541759-161550737 | ||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||
Band | q23.3 | ||||||||||||||||||
Transcripts | |||||||||||||||||||
Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||
Species
Mus musculus
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Gene ID
Gene Order
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Pathways | |||||||||||||||||||
NETPATH |
RANKL pathway
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REACTOME |
Regulation of actin dynamics for phagocytic cup formation pathway
Role of phospholipids in phagocytosis pathway
FCGR activation pathway
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell pathway
Innate Immune System pathway
Adaptive Immune System pathway
Immune System pathway
Fcgamma receptor (FCGR) dependent phagocytosis pathway
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KEGG |
Natural killer cell mediated cytotoxicity pathway
Systemic lupus erythematosus pathway
Fc gamma R-mediated phagocytosis pathway
Leishmaniasis pathway
Staphylococcus aureus infection pathway
Osteoclast differentiation pathway
Phagosome pathway
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INOH | |||||||||||||||||||
PID NCI | |||||||||||||||||||
Cross-References | |||||||||||||||||||
SwissProt | |||||||||||||||||||
TrEMBL | |||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | |||||||||||||||||||
UniGene | Hs.372679 Hs.673288 | ||||||||||||||||||
RefSeq | NM_000569 NM_001127592 NM_001127593 NM_001127595 NM_001127596 XM_006711211 | ||||||||||||||||||
HUGO | |||||||||||||||||||
OMIM | |||||||||||||||||||
CCDS | CCDS1232 CCDS44266 | ||||||||||||||||||
HPRD | 00903 | ||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | |||||||||||||||||||
GenPept | |||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||