Version 5.4
Homo sapiens Gene: HSD17B7
Summary
InnateDB Gene IDBG-104404.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HSD17B7
Gene Name hydroxysteroid (17-beta) dehydrogenase 7
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000132196
Encoded Proteins
IDBP-104406
hydroxysteroid (17-beta) dehydrogenase 7
IDBP-104414
hydroxysteroid (17-beta) dehydrogenase 7
IDBP-104418
hydroxysteroid (17-beta) dehydrogenase 7
IDBP-594142
hydroxysteroid (17-beta) dehydrogenase 7
IDBP-812223
hydroxysteroid (17-beta) dehydrogenase 7
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary HSD17B7 encodes an enzyme that functions both as a 17-beta-hydroxysteroid dehydrogenase (EC 1.1.1.62) in the biosynthesis of sex steroids and as a 3-ketosteroid reductase (EC 1.1.1.270) in the biosynthesis of cholesterol (Marijanovic et al., 2003 [PubMed 12829805]).[supplied by OMIM, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:162790702-162812817
Strand Forward strand
Band q23.3
Transcripts
ENST00000254521 ENSP00000254521
ENST00000367915 ENSP00000356892
ENST00000367913 ENSP00000356889
ENST00000485405
ENST00000463037
ENST00000466176 ENSP00000436334
ENST00000484251
ENST00000494450
ENST00000470195 ENSP00000476930
ENST00000488656
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 7 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000253 3-keto sterol reductase activity
GO:0003824 catalytic activity
GO:0004303 estradiol 17-beta-dehydrogenase activity
GO:0005148 prolactin receptor binding
GO:0016491 oxidoreductase activity
GO:0050662 coenzyme binding
Biological Process
GO:0006695 cholesterol biosynthetic process
GO:0006703 estrogen biosynthetic process
GO:0008152 metabolic process
GO:0044281 small molecule metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026675
View Gene Order
ENSBTAG00000005976
Not yet available
Pathways
NETPATH
REACTOME
REACT_9405
Cholesterol biosynthesis pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_111217
Metabolism pathway
KEGG
hsa00140
Steroid hormone biosynthesis pathway
hsa00100
Steroid biosynthesis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.492925 Hs.595928
RefSeq NM_016371
HUGO
OMIM
CCDS CCDS1242
HPRD 05996
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca