InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: RXRG

Summary

InnateDB Gene

IDBG-104461.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RXRG

Gene Name

retinoid X receptor, gamma

Synonyms

NR2B3; RXRC

Species

Homo sapiens

Ensembl Gene

ENSG00000143171

Encoded Proteins

IDBP-104465

retinoid X receptor, gamma

IDBP-808333

retinoid X receptor, gamma

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the antiproliferative effects of retinoic acid (RA). This receptor forms dimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene is expressed at significantly lower levels in non-small cell lung cancer cells. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jun 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:165400917-165445355

Strand

Reverse strand

Band

q23.3

Transcripts

ENST00000359842	ENSP00000352900
ENST00000470566
ENST00000465764
ENST00000619224	ENSP00000482458

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	33 [view]
Protein-Protein	32 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003707	steroid hormone receptor activity
GO:0004886	9-cis retinoic acid receptor activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0007422	peripheral nervous system development
GO:0007507	heart development
GO:0007519	skeletal muscle tissue development
GO:0010467	gene expression
GO:0014070	response to organic cyclic compound
GO:0030182	neuron differentiation
GO:0031641	regulation of myelination
GO:0032526	response to retinoic acid
GO:0032870	cellular response to hormone stimulus
GO:0043401	steroid hormone mediated signaling pathway
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048384	retinoic acid receptor signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000015843

View Gene Order

ENSBTAG00000016801

Not yet available

Pathways

NETPATH

REACTOME

REACT_15525

Nuclear Receptor transcription pathway pathway

REACT_12627

Generic Transcription Pathway pathway

REACT_71

Gene Expression pathway

KEGG

hsa05223

Non-small cell lung cancer pathway

hsa05216

Thyroid cancer pathway

hsa05222

Small cell lung cancer pathway

hsa03320

PPAR signaling pathway pathway

hsa04920

Adipocytokine signaling pathway pathway

hsa05200

Pathways in cancer pathway

INOH

PID NCI

Cross-References

SwissProt

P48443

TrEMBL

F1D8Q7

UniProt Splice Variant

Entrez Gene

6258

UniGene

RefSeq

NM_006917 NM_001256570 NM_001256571

HUGO

HGNC:10479

OMIM

180247

CCDS

CCDS1248 CCDS72970

HPRD

01579

IMGT

EMBL

AB593015 AL160058 BC012063 CH471067 CR456705 HQ692845 U38480

GenPept

AAA80681 AAH12063 ADZ17356 BAJ83970 CAC00596 CAG32986 EAW90745

RNA Seq Atlas

6258