Version 5.4
Homo sapiens Gene: GPR161
Summary
InnateDB Gene IDBG-104596.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GPR161
Gene Name G protein-coupled receptor 161
Synonyms RE2
Species Homo sapiens
Ensembl Gene ENSG00000143147
Encoded Proteins
IDBP-104598
G protein-coupled receptor 161
IDBP-104600
G protein-coupled receptor 161
IDBP-104602
G protein-coupled receptor 161
IDBP-104604
G protein-coupled receptor 161
IDBP-587069
G protein-coupled receptor 161
IDBP-598890
G protein-coupled receptor 161
IDBP-583755
G protein-coupled receptor 161
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Upon ligand binding, G protein-coupled receptors, such as GPR161, activate cytoplasmic G proteins (see GNAS, MIM 139320), allowing the receptors to transduce extracellular signals across the plasma membrane into the cell. Phosphorylation of the receptor attenuates signaling (Matteson et al., 2008 [PubMed 18250320]).[supplied by OMIM, Aug 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:168079543-168137667
Strand Reverse strand
Band q24.2
Transcripts
ENST00000367838 ENSP00000356812
ENST00000271357 ENSP00000271357
ENST00000367836 ENSP00000356810
ENST00000367835 ENSP00000356809
ENST00000478868
ENST00000493800
ENST00000485232
ENST00000546300 ENSP00000444348
ENST00000539777 ENSP00000437576
ENST00000537209 ENSP00000441039
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
Biological Process
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007275 multicellular organismal development
GO:0030819 positive regulation of cAMP biosynthetic process
GO:1901621 negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning
Cellular Component
GO:0016021 integral component of membrane
GO:0055037 recycling endosome
GO:0060170 ciliary membrane
GO:0072372 primary cilium
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000040836
View Gene Order
ENSBTAG00000000616
Not yet available
Pathways
NETPATH
REACTOME
REACT_228134
Signaling by Hedgehog pathway
REACT_111102
Signal Transduction pathway
REACT_267634
Hedgehog 'off' state pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q8N6U8
TrEMBL
UniProt Splice Variant
Entrez Gene 23432
UniGene Hs.271809
RefSeq NM_001267613 NM_001267609 NM_001267610 NM_001267611 NM_001267612 NM_001267614 NM_153832 XM_005245055 XM_005245056 XM_005245057 XM_006711251 XM_006711252 XM_006711253
HUGO HGNC:23694
OMIM 612250
CCDS CCDS58044 CCDS1268 CCDS58042 CCDS58043 CCDS58045 CCDS72978
HPRD 17070
IMGT
EMBL AF091890 AK056040 AK122656 AK298797 AK298850 AK299634 AL033532 AY275468 BC028163
GenPept AAC61598 AAH28163 AAP32300 BAG51611 BAG53646 BAH12873 BAH12884 BAH13082 CAI22622 CAI22623
RNA Seq Atlas 23432

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca