Version 5.4
Homo sapiens Gene: TSPO
Summary
InnateDB Gene IDBG-10470.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TSPO
Gene Name translocator protein (18kDa)
Synonyms BPBS; BZRP; DBI; IBP; MBR; mDRC; PBR; PBS; pk18; PKBS; PTBR
Species Homo sapiens
Ensembl Gene ENSG00000100300
Encoded Proteins
IDBP-10472
translocator protein (18kDa)
IDBP-10474
translocator protein (18kDa)
IDBP-237863
translocator protein (18kDa)
IDBP-379182
translocator protein (18kDa)
IDBP-719908
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Present mainly in the mitochondrial compartment of peripheral tissues, the protein encoded by this gene interacts with some benzodiazepines and has different affinities than its endogenous counterpart. The protein is a key factor in the flow of cholesterol into mitochondria to permit the initiation of steroid hormone synthesis. Alternatively spliced transcript variants have been reported; one of the variants lacks an internal exon and is considered non-coding, and the other variants encode the same protein. [provided by RefSeq, Feb 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:43151514-43163242
Strand Forward strand
Band q13.2
Transcripts
ENST00000337554 ENSP00000338004
ENST00000329563 ENSP00000328973
ENST00000396265 ENSP00000379563
ENST00000428336 ENSP00000405685
ENST00000472378
ENST00000583777 ENSP00000463495
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 3 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005497 androgen binding
GO:0005515 protein binding
GO:0008503 benzodiazepine receptor activity
GO:0015485 cholesterol binding
Biological Process
GO:0006626 protein targeting to mitochondrion
GO:0006694 steroid biosynthetic process
GO:0006783 heme biosynthetic process
GO:0006811 ion transport
GO:0006820 anion transport
GO:0006821 chloride transport
GO:0006915 apoptotic process
GO:0007268 synaptic transmission
GO:0007568 aging
GO:0008202 steroid metabolic process
GO:0008283 cell proliferation
GO:0008347 glial cell migration
GO:0010042 response to manganese ion
GO:0010266 response to vitamin B1
GO:0010940 positive regulation of necrotic cell death
GO:0014012 peripheral nervous system axon regeneration
GO:0030325 adrenal gland development
GO:0032374 regulation of cholesterol transport
GO:0032570 response to progesterone
GO:0032720 negative regulation of tumor necrosis factor production
GO:0033574 response to testosterone
GO:0042493 response to drug
GO:0043065 positive regulation of apoptotic process
GO:0045019 negative regulation of nitric oxide biosynthetic process
GO:0048265 response to pain
GO:0048266 behavioral response to pain
GO:0048678 response to axon injury
GO:0050810 regulation of steroid biosynthetic process
GO:0051901 positive regulation of mitochondrial depolarization
GO:0051928 positive regulation of calcium ion transport
GO:0060242 contact inhibition
GO:0060252 positive regulation of glial cell proliferation
GO:0060253 negative regulation of glial cell proliferation
GO:0071222 cellular response to lipopolysaccharide
GO:0071294 cellular response to zinc ion
GO:0071476 cellular hypotonic response
GO:2000379 positive regulation of reactive oxygen species metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0016021 integral component of membrane
GO:0031965 nuclear membrane
GO:0043231 intracellular membrane-bounded organelle
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000041736
View Gene Order
ENSBTAG00000018073
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04080
Neuroactive ligand-receptor interaction pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_000714 NM_001256530 NM_001256531
HUGO
OMIM
CCDS CCDS33661
HPRD 15913
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca