Version 5.4
Homo sapiens Gene: PRDX6
Summary
InnateDB Gene IDBG-104872.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PRDX6
Gene Name peroxiredoxin 6
Synonyms 1-Cys; aiPLA2; AOP2; HEL-S-128m; NSGPx; p29; PRX
Species Homo sapiens
Ensembl Gene ENSG00000117592
Encoded Proteins
IDBP-104874
peroxiredoxin 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the thiol-specific antioxidant protein family. This protein is a bifunctional enzyme with two distinct active sites. It is involved in redox regulation of the cell; it can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. It may play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:173477266-173488807
Strand Forward strand
Band q25.1
Transcripts
ENST00000340385 ENSP00000342026
ENST00000460950
ENST00000470017
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 62 experimentally validated interaction(s) in this database.
Experimentally validated
Total 62 [view]
Protein-Protein 62 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004602 glutathione peroxidase activity
GO:0004623 phospholipase A2 activity
GO:0005515 protein binding
GO:0016209 antioxidant activity
GO:0016491 oxidoreductase activity
GO:0051920 peroxiredoxin activity
Biological Process
GO:0006979 response to oxidative stress
GO:0009395 phospholipid catabolic process
GO:0042744 hydrogen peroxide catabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005764 lysosome
GO:0005829 cytosol
GO:0016020 membrane
GO:0016023 cytoplasmic membrane-bounded vesicle
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026701
View Gene Order
ENSBTAG00000004855
Not yet available
Pathways
NETPATH
REACTOME
REACT_120956
Cellular responses to stress pathway
REACT_172715
Detoxification of Reactive Oxygen Species pathway
KEGG
hsa00360
Phenylalanine metabolism pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.120
RefSeq NM_004905
HUGO
OMIM
CCDS CCDS1307
HPRD 03817
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca