Version 5.4
Homo sapiens Gene: DARS2
Summary
InnateDB Gene IDBG-104901.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DARS2
Gene Name aspartyl-tRNA synthetase 2, mitochondrial
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000117593
Encoded Proteins
IDBP-104903
aspartyl-tRNA synthetase 2, mitochondrial
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the class-II aminoacyl-tRNA synthetase family. It is a mitochondrial enzyme that specifically aminoacylates aspartyl-tRNA. Mutations in this gene are associated with leukoencephalopathy with brainstem and spinal cord involvement and lactate elevation (LBSL). [provided by RefSeq, Nov 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:173824503-173858546
Strand Forward strand
Band q25.1
Transcripts
ENST00000361951 ENSP00000355086
ENST00000471476
ENST00000460076
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000049 tRNA binding
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004815 aspartate-tRNA ligase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016874 ligase activity
GO:0042803 protein homodimerization activity
GO:0050560 aspartate-tRNA(Asn) ligase activity
Biological Process
GO:0006418 tRNA aminoacylation for protein translation
GO:0010467 gene expression
GO:0043039 tRNA aminoacylation
GO:0070145 mitochondrial asparaginyl-tRNA aminoacylation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026709
View Gene Order
ENSBTAG00000004358
Not yet available
Pathways
NETPATH
REACTOME
REACT_15302
Mitochondrial tRNA aminoacylation pathway
REACT_15482
tRNA Aminoacylation pathway
REACT_71
Gene Expression pathway
KEGG
hsa00970
Aminoacyl-tRNA biosynthesis pathway
INOH
PID NCI
Cross-References
SwissProt Q6PI48
TrEMBL A0A024R8Z9 Q9H9J7
UniProt Splice Variant
Entrez Gene 55157
UniGene Hs.647707 Hs.667016
RefSeq NM_018122
HUGO HGNC:25538
OMIM 610956
CCDS CCDS1311
HPRD
IMGT
EMBL AK022754 AL109921 BC045173 CH471067
GenPept AAH45173 BAB14228 CAI20380 EAW90961 EAW90962
RNA Seq Atlas 55157

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca