Version 5.4
Homo sapiens Gene: RC3H1
Summary
InnateDB Gene IDBG-104922.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RC3H1
Gene Name ring finger and CCCH-type domains 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000135870
Encoded Proteins
IDBP-104924
ring finger and CCCH-type domains 1
IDBP-104926
ring finger and CCCH-type domains 1
IDBP-104930
ring finger and CCCH-type domains 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary RC3H1, or roquin, encodes a highly conserved member of the RING type ubiquitin ligase protein family (Vinuesa et al., 2005 [PubMed 15917799]). The roquin protein is distinguished by the presence of a CCCH zinc finger found in RNA-binding proteins, and localization to cytosolic RNA granules implicated in regulating mRNA translation and stability.[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:173931214-174022297
Strand Reverse strand
Band q25.1
Transcripts
ENST00000367696 ENSP00000356669
ENST00000258349 ENSP00000258349
ENST00000367694 ENSP00000356667
ENST00000479099
ENST00000484867
ENST00000531594
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003729 mRNA binding
GO:0003730 mRNA 3'-UTR binding
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0044822 poly(A) RNA binding
GO:0046872 metal ion binding
Biological Process
GO:0000956 nuclear-transcribed mRNA catabolic process
GO:0001782 B cell homeostasis
GO:0002634 regulation of germinal center formation
GO:0002635 negative regulation of germinal center formation
GO:0010468 regulation of gene expression
GO:0010608 posttranscriptional regulation of gene expression
GO:0016567 protein ubiquitination
GO:0030889 negative regulation of B cell proliferation
GO:0033962 cytoplasmic mRNA processing body assembly
GO:0042098 T cell proliferation
GO:0043029 T cell homeostasis
GO:0043488 regulation of mRNA stability
GO:0045623 negative regulation of T-helper cell differentiation
GO:0046007 negative regulation of activated T cell proliferation
GO:0048535 lymph node development
GO:0048536 spleen development
GO:0050856 regulation of T cell receptor signaling pathway
GO:0061470 T follicular helper cell differentiation
GO:1901224 positive regulation of NIK/NF-kappaB signaling
Cellular Component
GO:0000932 cytoplasmic mRNA processing body
GO:0005737 cytoplasm
GO:0010494 cytoplasmic stress granule
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000040423
View Gene Order
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.30258 Hs.596653 Hs.608971 Hs.618818 Hs.624605
RefSeq NM_001300850 NM_001300851 NM_172071 XM_005244919 XM_006711183
HUGO
OMIM
CCDS CCDS30940 CCDS72987
HPRD 13913
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca