Version 5.4
Homo sapiens Gene: SRSF5
Summary
InnateDB Gene IDBG-10497.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SRSF5
Gene Name serine/arginine-rich splicing factor 5
Synonyms HRS; SFRS5; SRP40
Species Homo sapiens
Ensembl Gene ENSG00000100650
Encoded Proteins
IDBP-241722
serine/arginine-rich splicing factor 5
IDBP-600334
serine/arginine-rich splicing factor 5
IDBP-583334
serine/arginine-rich splicing factor 5
IDBP-589493
serine/arginine-rich splicing factor 5
IDBP-601800
serine/arginine-rich splicing factor 5
IDBP-596234
serine/arginine-rich splicing factor 5
IDBP-807864
serine/arginine-rich splicing factor 5
IDBP-592921
serine/arginine-rich splicing factor 5
IDBP-587826
serine/arginine-rich splicing factor 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:69726900-69772005
Strand Forward strand
Band q24.1
Transcripts
ENST00000394366 ENSP00000377892
ENST00000553521 ENSP00000452123
ENST00000554465
ENST00000553548 ENSP00000452400
ENST00000553369 ENSP00000452449
ENST00000557435
ENST00000557154 ENSP00000451088
ENST00000553635 ENSP00000451391
ENST00000556184
ENST00000557460
ENST00000556587
ENST00000555547 ENSP00000474409
ENST00000556436
ENST00000555412
ENST00000555349 ENSP00000452090
ENST00000554021 ENSP00000450918
ENST00000556330
ENST00000556647
ENST00000554929
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 107 experimentally validated interaction(s) in this database.
Experimentally validated
Total 107 [view]
Protein-Protein 104 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
GO:0050733 RS domain binding
Biological Process
GO:0000398 mRNA splicing, via spliceosome
GO:0006366 transcription from RNA polymerase II promoter
GO:0006369 termination of RNA polymerase II transcription
GO:0006376 mRNA splice site selection
GO:0006397 mRNA processing
GO:0006406 mRNA export from nucleus
GO:0008380 RNA splicing
GO:0009611 response to wounding
GO:0010467 gene expression
GO:0031124 mRNA 3'-end processing
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0016607 nuclear speck
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000021134
View Gene Order
ENSBTAG00000011596
Not yet available
Pathways
NETPATH
REACTOME
REACT_1849
mRNA 3'-end processing pathway
REACT_467
mRNA Splicing - Major Pathway pathway
REACT_1597
Transport of Mature mRNA derived from an Intron-Containing Transcript pathway
REACT_125
Processing of Capped Intron-Containing Pre-mRNA pathway
REACT_387
Cleavage of Growing Transcript in the Termination Region pathway
REACT_894
RNA Polymerase II Transcription Termination pathway
REACT_1366
RNA Polymerase II Transcription pathway
REACT_1281
Transport of Mature Transcript to Cytoplasm pathway
REACT_1735
mRNA Splicing pathway
REACT_71
Gene Expression pathway
KEGG
hsa03040
Spliceosome pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.632326 Hs.734522
RefSeq NM_001039465 NM_006925 XM_005267998 XM_005267999 XM_005268000
HUGO
OMIM
CCDS CCDS32109
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca