InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: TNR

Summary

InnateDB Gene

IDBG-104981.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TNR

Gene Name

tenascin R

Synonyms

TN-R

Species

Homo sapiens

Ensembl Gene

ENSG00000116147

Encoded Proteins

IDBP-104983

tenascin R (restrictin, janusin)

IDBP-104985

tenascin R (restrictin, janusin)

IDBP-389729

tenascin R (restrictin, janusin)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Tenascin-R (TNR) is an extracellular matix protein expressed primarily in the central nervous system. It is a member of the tenascin (TN) gene family, which includes at least 3 genes in mammals: TNC (or hexabrachion; MIM 187380), TNX (TNXB; MIM 600985), and TNR (Erickson, 1993 [PubMed 7694605]). The genes are expressed in distinct tissues at different times during embryonic development and are present in adult tissues.[supplied by OMIM, Mar 2008]
This gene encodes a member of the tenascin family of extracellular matrix glycoproteins. The encoded protein is restricted to the central nervous system. The protein may play a role in neurite outgrowth, neural cell adhesion and modulation of sodium channel function. It is a constituent of perineuronal nets. [provided by RefSeq, Aug 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:175315194-175743770

Strand

Reverse strand

Band

q25.1

Transcripts

ENST00000367674	ENSP00000356646
ENST00000263525	ENSP00000263525
ENST00000422274	ENSP00000403413

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0007155	cell adhesion
GO:0007158	neuron cell-cell adhesion
GO:0007411	axon guidance
GO:0008306	associative learning
GO:0010977	negative regulation of neuron projection development
GO:0022029	telencephalon cell migration
GO:0022408	negative regulation of cell-cell adhesion
GO:0030198	extracellular matrix organization
GO:0030517	negative regulation of axon extension
GO:0035641	locomotory exploration behavior
GO:0048692	negative regulation of axon extension involved in regeneration
GO:0050804	regulation of synaptic transmission
GO:0050805	negative regulation of synaptic transmission
GO:0050808	synapse organization
GO:0050885	neuromuscular process controlling balance
GO:0051968	positive regulation of synaptic transmission, glutamatergic
GO:0051971	positive regulation of transmission of nerve impulse
GO:0060291	long-term synaptic potentiation

Cellular Component

GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0009986	cell surface
GO:0045121	membrane raft
GO:0072534	perineuronal net

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000015829

View Gene Order

ENSBTAG00000011706

Not yet available

Pathways

NETPATH

REACTOME

REACT_118779

Extracellular matrix organization pathway

REACT_163906

ECM proteoglycans pathway

KEGG

hsa04512

ECM-receptor interaction pathway

hsa04510

Focal adhesion pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.659864

RefSeq

NM_003285

HUGO

OMIM

CCDS

CCDS1318

HPRD

03589

IMGT

EMBL

GenPept

RNA Seq Atlas