Version 5.4
Homo sapiens Gene: PAPPA2
Summary
InnateDB Gene IDBG-105006.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PAPPA2
Gene Name pappalysin 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000116183
Encoded Proteins
IDBP-105008
pappalysin 2
IDBP-105010
pappalysin 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the pappalysin family of metzincin metalloproteinases. The encoded protein cleaves insulin-like growth factor-binding protein 5 and is thought to be a local regulator of insulin-like growth factor (IGF) bioavailability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:176463171-176845605
Strand Forward strand
Band q25.2
Transcripts
ENST00000367662 ENSP00000356634
ENST00000367661 ENSP00000356633
ENST00000493665
ENST00000486075
ENST00000479836
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0001558 regulation of cell growth
GO:0006508 proteolysis
GO:0030154 cell differentiation
GO:0044267 cellular protein metabolic process
GO:0060349 bone morphogenesis
Cellular Component
GO:0005576 extracellular region
GO:0005622 intracellular
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000073530
View Gene Order
ENSBTAG00000018303
Not yet available
Pathways
NETPATH
REACTOME
REACT_15428
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) pathway
REACT_17015
Metabolism of proteins pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_020318 NM_021936 XM_005245422
HUGO
OMIM
CCDS CCDS41438 CCDS41439
HPRD 10156
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca