Version 5.4
Homo sapiens Gene: RGS8
Summary
InnateDB Gene IDBG-105256.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RGS8
Gene Name regulator of G-protein signaling 8
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000135824
Encoded Proteins
IDBP-105258
regulator of G-protein signaling 8
IDBP-105260
regulator of G-protein signaling 8
IDBP-105264
regulator of G-protein signaling 8
IDBP-474414
regulator of G-protein signaling 8
IDBP-480914
regulator of G-protein signaling 8
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the regulator of G protein signaling (RGS) family and encodes a protein with a single RGS domain. Regulator of G protein signaling (RGS) proteins are regulatory and structural components of G protein-coupled receptor complexes. They accelerate transit through the cycle of GTP binding and hydrolysis to GDP, thereby terminating signal transduction, but paradoxically, also accelerate receptor-stimulated activation. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:182646104-182684576
Strand Reverse strand
Band q25.3
Transcripts
ENST00000367557 ENSP00000356528
ENST00000258302 ENSP00000258302
ENST00000367556 ENSP00000356527
ENST00000483095 ENSP00000426289
ENST00000491420
ENST00000508450 ENSP00000427076
ENST00000515211
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005096 GTPase activator activity
Biological Process
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway
GO:0038032 termination of G-protein coupled receptor signaling pathway
GO:0043547 positive regulation of GTPase activity
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000042671
View Gene Order
ENSBTAG00000026481
Not yet available
Pathways
NETPATH
REACTOME
REACT_19231
G alpha (i) signalling events pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
KEGG
INOH
INOH website
GPCR signaling pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.458417
RefSeq NM_001102450 NM_033345 XM_005245555 XM_006711597
HUGO
OMIM
CCDS CCDS1349 CCDS41443
HPRD 06221
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca