InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: DHX9

Summary

InnateDB Gene

IDBG-105280.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DHX9

Gene Name

DEAH (Asp-Glu-Ala-His) box polypeptide 9

Synonyms

DDX9; LKP; NDH2; NDHII; RHA

Species

Homo sapiens

Ensembl Gene

ENSG00000135829

Encoded Proteins

IDBP-105282

DEAH (Asp-Glu-Ala-His) box polypeptide 9

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 20696886

DHX9 interacts with CpG-B and was associated with TNF-alpha and IL-6 production and NF-kappaB activation upon CpG-B stimulation. DHX9 is localized in the cytosol and is found to bind to TLR domain of MYD88.

Entrez Gene

Summary

This gene encodes a member of the DEAH-containing family of RNA helicases. The encoded protein is an enzyme that catalyzes the ATP-dependent unwinding of double-stranded RNA and DNA-RNA complexes. This protein localizes to both the nucleus and the cytoplasm and functions as a transcriptional regulator. This protein may also be involved in the expression and nuclear export of retroviral RNAs. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 11 and 13.[provided by RefSeq, Feb 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:182839369-182887751

Strand

Forward strand

Band

q25.3

Transcripts

ENST00000367549	ENSP00000356520
ENST00000483416
ENST00000479271
ENST00000477802
ENST00000490519
ENST00000474446
ENST00000485081
ENST00000473076

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 246 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	246 [view]
Protein-Protein	246 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001085	RNA polymerase II transcription factor binding
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003724	RNA helicase activity
GO:0004003	ATP-dependent DNA helicase activity
GO:0004004	ATP-dependent RNA helicase activity
GO:0004386	helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000398	mRNA splicing, via spliceosome
GO:0001649	osteoblast differentiation
GO:0006200	ATP catabolic process
GO:0007623	circadian rhythm
GO:0008380	RNA splicing
GO:0010467	gene expression
GO:0032481	positive regulation of type I interferon production
GO:0032508	DNA duplex unwinding
GO:0034605	cellular response to heat
GO:0045087	innate immune response (InnateDB)
GO:0070934	CRD-mediated mRNA stabilization

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0005829	cytosol
GO:0016020	membrane
GO:0030529	ribonucleoprotein complex
GO:0036464	cytoplasmic ribonucleoprotein granule
GO:0070937	CRD-mediated mRNA stability complex