InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: NCF2

Summary

InnateDB Gene

IDBG-105312.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NCF2

Gene Name

neutrophil cytosolic factor 2

Synonyms

NCF-2; NOXA2; P67-PHOX; P67PHOX

Species

Homo sapiens

Ensembl Gene

ENSG00000116701

Encoded Proteins

IDBP-105314

neutrophil cytosolic factor 2

IDBP-105316

neutrophil cytosolic factor 2

IDBP-389799

neutrophil cytosolic factor 2

IDBP-389800

neutrophil cytosolic factor 2

IDBP-389801

neutrophil cytosolic factor 2

IDBP-389802

neutrophil cytosolic factor 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes neutrophil cytosolic factor 2, the 67-kilodalton cytosolic subunit of the multi-protein NADPH oxidase complex found in neutrophils. This oxidase produces a burst of superoxide which is delivered to the lumen of the neutrophil phagosome. Mutations in this gene, as well as in other NADPH oxidase subunits, can result in chronic granulomatous disease, a disease that causes recurrent infections by catalase-positive organisms. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:183555563-183590876

Strand

Reverse strand

Band

q25.3

Transcripts

ENST00000367536	ENSP00000356506
ENST00000367535	ENSP00000356505
ENST00000418089	ENSP00000407217
ENST00000413720	ENSP00000399294
ENST00000420553	ENSP00000397228
ENST00000419402	ENSP00000406198
ENST00000469280

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 38 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	38 [view]
Protein-Protein	35 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0009055	electron carrier activity
GO:0048365	Rac GTPase binding

Biological Process

GO:0002474	antigen processing and presentation of peptide antigen via MHC class I
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0006801	superoxide metabolic process
GO:0006968	cellular defense response
GO:0007568	aging
GO:0009749	response to glucose
GO:0014070	response to organic cyclic compound
GO:0014823	response to activity
GO:0032496	response to lipopolysaccharide
GO:0032570	response to progesterone
GO:0032870	cellular response to hormone stimulus
GO:0033993	response to lipid
GO:0034616	response to laminar fluid shear stress
GO:0042493	response to drug
GO:0042554	superoxide anion generation
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0043525	positive regulation of neuron apoptotic process
GO:0045087	innate immune response
GO:0045730	respiratory burst
GO:0045777	positive regulation of blood pressure
GO:0051701	interaction with host
GO:0055093	response to hyperoxia
GO:0090382	phagosome maturation

Cellular Component

GO:0001669	acrosomal vesicle
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0016020	membrane
GO:0032010	phagolysosome
GO:0043020	NADPH oxidase complex