Version 5.4
Homo sapiens Gene: UCHL5
Summary
InnateDB Gene IDBG-105454.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol UCHL5
Gene Name ubiquitin carboxyl-terminal hydrolase L5
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000116750
Encoded Proteins
IDBP-105456
ubiquitin carboxyl-terminal hydrolase L5
IDBP-105458
ubiquitin carboxyl-terminal hydrolase L5
IDBP-105464
ubiquitin carboxyl-terminal hydrolase L5
IDBP-105466
ubiquitin carboxyl-terminal hydrolase L5
IDBP-105468
ubiquitin carboxyl-terminal hydrolase L5
IDBP-105470
ubiquitin carboxyl-terminal hydrolase L5
IDBP-389823
ubiquitin carboxyl-terminal hydrolase L5
IDBP-389824
ubiquitin carboxyl-terminal hydrolase L5
IDBP-389825
ubiquitin carboxyl-terminal hydrolase L5
IDBP-389826
ubiquitin carboxyl-terminal hydrolase L5
IDBP-389827
ubiquitin carboxyl-terminal hydrolase L5
IDBP-389828
ubiquitin carboxyl-terminal hydrolase L5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 1:193012250-193060080
Strand Reverse strand
Band q31.2
Transcripts
ENST00000367455 ENSP00000356425
ENST00000367454 ENSP00000356424
ENST00000367451 ENSP00000356421
ENST00000367450 ENSP00000356420
ENST00000367449 ENSP00000356419
ENST00000367448 ENSP00000356418
ENST00000420791 ENSP00000408720
ENST00000449480 ENSP00000402847
ENST00000443327 ENSP00000391153
ENST00000416915 ENSP00000392416
ENST00000421683 ENSP00000389563
ENST00000417752 ENSP00000412265
ENST00000483156
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 221 experimentally validated interaction(s) in this database.
Experimentally validated
Total 221 [view]
Protein-Protein 220 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004843 ubiquitin-specific protease activity
GO:0004866 endopeptidase inhibitor activity
GO:0005515 protein binding
GO:0008242 omega peptidase activity
GO:0044822 poly(A) RNA binding
GO:0070628 proteasome binding
Biological Process
GO:0006281 DNA repair
GO:0006310 DNA recombination
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0010951 negative regulation of endopeptidase activity
GO:0016579 protein deubiquitination
GO:0021670 lateral ventricle development
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
GO:0030901 midbrain development
GO:0048853 forebrain morphogenesis
GO:0061136 regulation of proteasomal protein catabolic process
Cellular Component
GO:0000502 proteasome complex
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005829 cytosol
GO:0031011 Ino80 complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000018189
View Gene Order
ENSBTAG00000013620
Not yet available
Pathways
NETPATH
NetPath_7
TGF_beta_Receptor pathway
REACTOME
REACT_120727
Downregulation of TGF-beta receptor signaling pathway
REACT_120850
TGF-beta receptor signaling activates SMADs pathway
REACT_169107
SMAD4 MH2 Domain Mutants in Cancer pathway
REACT_169219
Loss of Function of SMAD4 in Cancer pathway
REACT_169398
Loss of Function of SMAD2/3 in Cancer pathway
REACT_169122
Signaling by TGF-beta Receptor Complex in Cancer pathway
REACT_169192
TGFBR2 MSI Frameshift Mutants in Cancer pathway
REACT_111102
Signal Transduction pathway
REACT_169165
SMAD2/3 MH2 Domain Mutants in Cancer pathway
REACT_169435
Loss of Function of TGFBR2 in Cancer pathway
REACT_169103
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
REACT_169263
TGFBR1 KD Mutants in Cancer pathway
REACT_169311
Loss of Function of TGFBR1 in Cancer pathway
REACT_169445
TGFBR1 LBD Mutants in Cancer pathway
REACT_169440
TGFBR2 Kinase Domain Mutants in Cancer pathway
REACT_116125
Disease pathway
REACT_6844
Signaling by TGF-beta Receptor Complex pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL Q5LJB1
UniProt Splice Variant
Entrez Gene 51377
UniGene Hs.145469
RefSeq NM_001199261 NM_001199262 NM_001199263 NM_015984 XM_005245245 XM_005245247 XM_005245248 XM_005245249 XM_006711373
HUGO HGNC:19678
OMIM 610667
CCDS CCDS1378 CCDS55668 CCDS55669 CCDS55670
HPRD 10293
IMGT
EMBL AL136370
GenPept
RNA Seq Atlas 51377

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca