Version 5.4
| Homo sapiens Gene: CFHR4 | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-105525.6 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | CFHR4 | ||||||||||||||||||
| Gene Name | complement factor H-related 4 | ||||||||||||||||||
| Synonyms | CFHL4; FHR-4; FHR4 | ||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Gene | ENSG00000134365 | ||||||||||||||||||
| Encoded Proteins |
complement factor H-related 4
complement factor H-related 4
complement factor H-related 4
complement factor H-related 4
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| Summary |
This gene is a member of the complement factor H (CFH) gene family, and encodes one of the 5 CFH-related (CFHR) proteins. These 5 genes are closely linked to the CFH gene on chromosome 1q31-q32. The CFHRs are secreted plasma proteins synthesized primarily by the hepatocytes, and composed of highly-related short consensus repeats (SCRs). This protein enhances the cofactor activity of CFH, and is involved in complement regulation. It can associate with lipoproteins and may play a role in lipid metabolism. Alternatively spliced transcript variants encoding different isoforms (varying in the number of SCRs) have been described for this gene. [provided by RefSeq, Jan 2011] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 1:196850241-196918972 | ||||||||||||||||||
| Strand | Forward strand | ||||||||||||||||||
| Band | q31.3 | ||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
| No orthologs found for this gene | |||||||||||||||||||
| Cross-References | |||||||||||||||||||
| SwissProt | Q92496 | ||||||||||||||||||
| TrEMBL | V9GYX2 | ||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | 10877 | ||||||||||||||||||
| UniGene | Hs.710100 | ||||||||||||||||||
| RefSeq | NM_001201550 NM_001201551 NM_006684 XM_006711128 XM_006711129 XM_006711130 XM_006711132 XM_006711134 | ||||||||||||||||||
| HUGO | HGNC:16979 | ||||||||||||||||||
| OMIM | 605337 | ||||||||||||||||||
| CCDS | CCDS41451 CCDS55671 | ||||||||||||||||||
| HPRD | |||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | AF190816 AJ640130 AK292752 AL139418 BC074957 BX248415 CH471067 X98337 | ||||||||||||||||||
| GenPept | AAF05951 AAH74957 BAF85441 CAA66980 CAG26679 CAH70075 CAI21980 EAW91266 | ||||||||||||||||||
| RNA Seq Atlas | 10877 | ||||||||||||||||||