InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ATP6V1G3

Summary

InnateDB Gene

IDBG-105600.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ATP6V1G3

Gene Name

ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G3

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000151418

Encoded Proteins

IDBP-105602

ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G3

IDBP-105606

ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G3

IDBP-105608

ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G3

IDBP-482132

ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'' and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene encodes one of three G subunit proteins. Transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:198523222-198540945

Strand

Reverse strand

Band

q31.3

Transcripts

ENST00000367382	ENSP00000356352
ENST00000281087	ENSP00000281087
ENST00000309309	ENSP00000309574
ENST00000489986	ENSP00000417171

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008553	hydrogen-exporting ATPase activity, phosphorylative mechanism
GO:0016820	hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
GO:0051117	ATPase binding

Biological Process

GO:0006879	cellular iron ion homeostasis
GO:0008286	insulin receptor signaling pathway
GO:0015992	proton transport
GO:0033572	transferrin transport
GO:0051701	interaction with host
GO:0055085	transmembrane transport
GO:0090382	phagosome maturation

Cellular Component

GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0016471	vacuolar proton-transporting V-type ATPase complex

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000026394

View Gene Order

ENSBTAG00000019890

Not yet available

Pathways

NETPATH

REACTOME

REACT_25283

Transferrin endocytosis and recycling pathway

REACT_25060

Iron uptake and transport pathway

REACT_1109

Insulin receptor recycling pathway

REACT_498

Signaling by Insulin receptor pathway

REACT_121256

Phagosomal maturation (early endosomal stage) pathway

REACT_15518

Transmembrane transport of small molecules pathway

REACT_111102

Signal Transduction pathway

REACT_121237

Latent infection of Homo sapiens with Mycobacterium tuberculosis pathway

REACT_116125

Disease pathway

KEGG

hsa05110

Vibrio cholerae infection pathway

hsa05120

Epithelial cell signaling in Helicobacter pylori infection pathway

hsa00190

Oxidative phosphorylation pathway

hsa04966

Collecting duct acid secretion pathway

hsa04145

Phagosome pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.127743

RefSeq

NM_133262 NM_133326 XM_006711163 XM_006724958

HUGO

OMIM

CCDS

CCDS1395 CCDS1396

HPRD

16526

IMGT

EMBL

GenPept

RNA Seq Atlas