Version 5.4
Homo sapiens Gene: PTPRC
Summary
InnateDB Gene IDBG-105609.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PTPRC
Gene Name protein tyrosine phosphatase, receptor type, C
Synonyms B220; CD45; CD45R; GP180; L-CA; LCA; LY5; T200
Species Homo sapiens
Ensembl Gene ENSG00000081237
Encoded Proteins
IDBP-105611
protein tyrosine phosphatase, receptor type, C
IDBP-105615
protein tyrosine phosphatase, receptor type, C
IDBP-105623
protein tyrosine phosphatase, receptor type, C
IDBP-105629
protein tyrosine phosphatase, receptor type, C
IDBP-389846
protein tyrosine phosphatase, receptor type, C
IDBP-389847
protein tyrosine phosphatase, receptor type, C
IDBP-389849
protein tyrosine phosphatase, receptor type, C
IDBP-601661
protein tyrosine phosphatase, receptor type, C
IDBP-722219
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 11201744
PTPRC (CD45) suppresses JAK (Janus kinase) kinases and negatively regulates cytokine receptor signaling by regulating interleukin-3-mediated cellular proliferation, erythropoietin-dependent haematopoiesis and antiviral responses in vitro and in vivo.
Entrez Gene
Summary The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jun 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:198638671-198757283
Strand Forward strand
Band q31.3
Transcripts
ENST00000367379 ENSP00000356349
ENST00000348564 ENSP00000306782
ENST00000367367 ENSP00000356337
ENST00000367364 ENSP00000356334
ENST00000391970
ENST00000442510 ENSP00000411355
ENST00000413409 ENSP00000405494
ENST00000427110
ENST00000418674 ENSP00000393360
ENST00000462363
ENST00000484135
ENST00000491302
ENST00000530727 ENSP00000433536
ENST00000529828 ENSP00000469141
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 72 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 72 [view]
Protein-Protein 72 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004725 protein tyrosine phosphatase activity
GO:0005001 transmembrane receptor protein tyrosine phosphatase activity
GO:0005515 protein binding
GO:0008201 heparin binding
GO:0016791 phosphatase activity
GO:0019901 protein kinase binding
GO:0043395 heparan sulfate proteoglycan binding
Biological Process
GO:0000187 activation of MAPK activity
GO:0001915 negative regulation of T cell mediated cytotoxicity
GO:0001916 positive regulation of T cell mediated cytotoxicity
GO:0001960 negative regulation of cytokine-mediated signaling pathway
GO:0002244 hematopoietic progenitor cell differentiation
GO:0002378 immunoglobulin biosynthetic process
GO:0002711 positive regulation of T cell mediated immunity
GO:0002923 regulation of humoral immune response mediated by circulating immunoglobulin
GO:0002925 positive regulation of humoral immune response mediated by circulating immunoglobulin
GO:0006469 negative regulation of protein kinase activity
GO:0006470 protein dephosphorylation
GO:0006933 negative regulation of cell adhesion involved in substrate-bound cell migration
GO:0007159 leukocyte cell-cell adhesion
GO:0007166 cell surface receptor signaling pathway
GO:0007411 axon guidance
GO:0010332 response to gamma radiation
GO:0016311 dephosphorylation
GO:0030183 B cell differentiation
GO:0030217 T cell differentiation
GO:0030890 positive regulation of B cell proliferation
GO:0031953 negative regulation of protein autophosphorylation
GO:0034113 heterotypic cell-cell adhesion
GO:0035335 peptidyl-tyrosine dephosphorylation
GO:0042098 T cell proliferation
GO:0042100 B cell proliferation
GO:0042102 positive regulation of T cell proliferation
GO:0043410 positive regulation of MAPK cascade
GO:0044770 cell cycle phase transition
GO:0045059 positive thymic T cell selection
GO:0045060 negative thymic T cell selection
GO:0045087 innate immune response (InnateDB)
GO:0045577 regulation of B cell differentiation
GO:0045582 positive regulation of T cell differentiation
GO:0045588 positive regulation of gamma-delta T cell differentiation
GO:0045860 positive regulation of protein kinase activity
GO:0046641 positive regulation of alpha-beta T cell proliferation
GO:0048304 positive regulation of isotype switching to IgG isotypes
GO:0048539 bone marrow development
GO:0048864 stem cell development
GO:0050732 negative regulation of peptidyl-tyrosine phosphorylation
GO:0050852 T cell receptor signaling pathway
GO:0050853 B cell receptor signaling pathway
GO:0050855 regulation of B cell receptor signaling pathway
GO:0050857 positive regulation of antigen receptor-mediated signaling pathway
GO:0051209 release of sequestered calcium ion into cytosol
GO:0051607 defense response to virus
GO:0051726 regulation of cell cycle
GO:2000473 positive regulation of hematopoietic stem cell migration
GO:2000648 positive regulation of stem cell proliferation
GO:2001236 regulation of extrinsic apoptotic signaling pathway
GO:2001238 positive regulation of extrinsic apoptotic signaling pathway
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005925 focal adhesion
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0045121 membrane raft
GO:0070062 extracellular vesicular exosome
GO:0071944 cell periphery
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026395
View Gene Order
ENSBTAG00000023144
Not yet available
Pathways
NETPATH
NetPath_11
TCR pathway
NetPath_12
BCR pathway
NetPath_15
IL3 pathway
REACTOME
KEGG
hsa04514
Cell adhesion molecules (CAMs) pathway
hsa04660
T cell receptor signaling pathway pathway
hsa05340
Primary immunodeficiency pathway
hsa04666
Fc gamma R-mediated phagocytosis pathway
INOH
PID NCI
cd8tcrpathway
TCR signaling in naïve CD8+ T cells
cxcr4_pathway
CXCR4-mediated signaling events
tcr_pathway
TCR signaling in naïve CD4+ T cells
bcr_5pathway
BCR signaling pathway
Cross-References
SwissProt
TrEMBL M9MML3 Q6QIM3 Q6QIN1 Q6QIN9 Q6QIQ5 Q6QIR3 Q9H3X6
UniProt Splice Variant
Entrez Gene 5788
UniGene Hs.599730 Hs.654514
RefSeq NM_001267798 NM_002838 NM_080921 XM_006711473 XM_006711474 XM_006711475
HUGO HGNC:9666
OMIM 151460
CCDS CCDS1397 CCDS1398 CCDS44291
HPRD 01050
IMGT
EMBL AL157402 AL355988 AY539659 AY539667 AY539683 AY539691 AY539699 M23461 M23462 M23463
GenPept AAG26082 AAS46922 AAS46938 AAS46946 AAS46954 AAS46962
RNA Seq Atlas 5788

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca