InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: NR5A2

Summary

InnateDB Gene

IDBG-105630.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NR5A2

Gene Name

nuclear receptor subfamily 5, group A, member 2

Synonyms

B1F; B1F2; CPF; FTF; FTZ-F1; FTZ-F1beta; hB1F-2; LRH-1; LRH1

Species

Homo sapiens

Ensembl Gene

ENSG00000116833

Encoded Proteins

IDBP-105632

nuclear receptor subfamily 5, group A, member 2

IDBP-105634

nuclear receptor subfamily 5, group A, member 2

IDBP-105638

nuclear receptor subfamily 5, group A, member 2

IDBP-389850

nuclear receptor subfamily 5, group A, member 2

IDBP-591085

nuclear receptor subfamily 5, group A, member 2

IDBP-593193

nuclear receptor subfamily 5, group A, member 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:200027602-200177424

Strand

Forward strand

Band

q32.1

Transcripts

ENST00000367362	ENSP00000356331
ENST00000236914	ENSP00000236914
ENST00000367357	ENSP00000356326
ENST00000447034	ENSP00000414888
ENST00000474307	ENSP00000436776
ENST00000544748	ENSP00000439116

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 37 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	37 [view]
Protein-Protein	33 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0003707	steroid hormone receptor activity
GO:0004879	ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005515	protein binding
GO:0005543	phospholipid binding
GO:0008270	zinc ion binding
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0008206	bile acid metabolic process
GO:0009790	embryo development
GO:0010467	gene expression
GO:0030522	intracellular receptor signaling pathway
GO:0031018	endocrine pancreas development
GO:0042127	regulation of cell proliferation
GO:0042592	homeostatic process
GO:0042632	cholesterol homeostasis
GO:0043401	steroid hormone mediated signaling pathway
GO:0045070	positive regulation of viral genome replication
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000026398

View Gene Order

ENSBTAG00000009265

Not yet available

Pathways

NETPATH

REACTOME

KEGG

hsa04950

Maturity onset diabetes of the young pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.33446

RefSeq

NM_001276464 NM_003822 NM_205860 XM_005245061 XM_005245062

HUGO

OMIM

CCDS

CCDS1400 CCDS1401 CCDS60383

HPRD

06830

IMGT

EMBL

GenPept

RNA Seq Atlas